Aims: The aim of this study was to evaluate the cross-cultural adaptation and examine the psychometric properties of the Indonesian version of the 35-item Nurse Professional Competence Scale Short Version (NPC Scale SV). Method: This descriptive cross-sectional study involved translation, cross-cultural adaptation and evaluation of psychometric properties. Data were collected from 352 registered nurses (RNs) working in various healthcare settings across Indonesia. The NPC Scale SV was translated into Bahasa Indonesia. Preliminary psychometric testing was conducted with content validation using an expert panel and pilot testing. Psychometric testing included confirmatory factor analysis (CFA), construct reliability, and finally the Model Fit. Results: The 35-item Bahasa Indonesia version (NPC Scale SV-INA) demonstrated six domains evident from the CFA. This was confirmed with fit indices: CMIN/df 1.346; GFI 0.914; NFI 0.967; TLI 0.989; CFI 0.991; and RMSEA 0.031. Factor loadings in each domain were more than 0.5 and showed good construct reliability (> 0.7). Conclusion: The NPC Scale SV-INA has been tested among RNs across Indonesia and evaluated from a cultural perspective.