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The Effects of Working Memory Updating Training in People with Parkinson’s Disease: Training Gain, Transfer, and Meaning
Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Department of Social and Psychological Studies (from 2013).ORCID iD: 0000-0002-9691-0185
2026 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cognitive deficits are common in Parkinson’s disease (PD) and reduce quality of life, yet they are often overlooked in clinical practice and respond poorly to standard medication. Working memory updating (WMU) training has shown to improve WMU performance and dopaminergic availability in healthy populations. As PD is characterized by dopaminergic depletion, WMU training may represent a promising intervention. This thesis investigated the feasibility, effects, and experience of WMU training in people with PD.

A feasibility study and single-subject study (Study I) indicated that WMU training is feasible, and improvements were observed in cognition, motor function, and functional brain response.

In Study II, 86 people with PD were randomized to 30 sessions of WMU training or active control. Findings demonstrated improvements immediately after training for the WMU group on cognitive tests that share cognitive processes with the training tasks, and these gains were maintained four months after training. Broader cognitive improvements were observed at follow-up, suggesting delayed transfer effects to untrained domains. Self-reported psychological health remained stable.

Study III focused on the experience of cognitive training via semi-structured interviews with 18 people with PD. Three themes were identified: commitment to the training, receiving feedback during training, and inspiration to apply strategies from training to everyday life.

In sum, this thesis provides evidence that WMU training in people with PD is feasible and leads to measurable cognitive benefits. Improvements were observed on tasks that share cognitive processes with the training, and after four months in broader cognitive domains. The findings further indicate that emotional, motivational, and metacognitive processes develop during training and transfer to everyday life. Together, these results suggest that WMU training can enhance aspects of cognitive ability and cognitive efficiency in people with PD.

Abstract [en]

Cognitive deficits are common in people with Parkinson’s disease (PD), reduce quality of life, and are poorly addressed by medication. This thesis investigated whether working memory updating (WMU) training can represent a promising cognitive intervention for people with PD. Across three studies, including a feasibility study, a randomized controlled trial, and a qualitative study, the thesis examined the feasibility, effects, and experience of WMU training. The results showed that WMU training is feasible and leads to measurable cognitive improvements. Immediate gains were observed on tasks that share cognitive processes with the training, and delayed improvements in broader cognitive domains. Participants also described emotional, motivational, and metacognitive changes during training that supported transfer to everyday life. Together, these findings may suggest that WMU training enhances both cognitive ability and cognitive efficiency in people with PD.

Place, publisher, year, edition, pages
Karlstads universitet, 2026. , p. 82
Series
Karlstad University Studies, ISSN 1403-8099 ; 2026:27
Keywords [en]
Parkinson's Disease, cognitive training, working memory updating, cognition, psychological health
National Category
Applied Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:kau:diva-109148DOI: 10.59217/lpob6725ISBN: 978-91-7867-703-0 (print)ISBN: 978-91-7867-704-7 (electronic)OAI: oai:DiVA.org:kau-109148DiVA, id: diva2:2048262
Public defence
2026-05-29, 11D257, Agardhsalen, Karlstad, 09:00 (English)
Opponent
Supervisors
Available from: 2026-05-08 Created: 2026-03-24 Last updated: 2026-06-11Bibliographically approved
List of papers
1. The Effects of Working Memory Updating Training in Parkinson’s Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response
Open this publication in new window or tab >>The Effects of Working Memory Updating Training in Parkinson’s Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response
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2021 (English)In: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 11, article id 587925Article in journal (Refereed) Published
Abstract [en]

In Parkinson’s disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject (FL) study were performed in which patients with PD completed computerized WM updating training. The outcome measures were the pre-post changes in criterion and transfer cognitive tests; cognitive complaints; psychological health; movement kinematics; and task-related BOLD signal. Participants in the feasibility study showed improvements on the criterion tests at post-test. FL displayed the largest improvements on the criterion tests and smaller improvements on transfer tests. Furthermore, FL reported improved cognitive performance in everyday life. A shorter onset latency and smoother upper-limb goal-directed movements were measured at post-test, as well as increased activation within the striatum and decreased activation throughout the fronto-parietal WM network. This two-part study demonstrated that WM updating training is feasible to complete for PD patients and that change occurred in FL at post-test in the domains of cognition, movement and functional brain response.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2021
Keywords
cognition, cognitive training, functional magnetic resonance imaging, movement kinematics, Parkinson’s disease, working memory
National Category
Neurosciences Psychology
Research subject
Medical Science; Psychology with an emphasis on medical psychology
Identifiers
urn:nbn:se:kau:diva-83352 (URN)10.3389/fpsyg.2020.587925 (DOI)2-s2.0-85100012546 (Scopus ID)
Available from: 2021-03-05 Created: 2021-03-05 Last updated: 2026-05-04Bibliographically approved
2. The Effects of Working Memory Updating Training on Cognition and Psychological Health in People with Parkinson’s Disease
Open this publication in new window or tab >>The Effects of Working Memory Updating Training on Cognition and Psychological Health in People with Parkinson’s Disease
Show others...
(English)Manuscript (preprint) (Other academic)
National Category
Applied Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:kau:diva-109147 (URN)
Available from: 2026-03-06 Created: 2026-03-06 Last updated: 2026-05-04Bibliographically approved
3. The experience of process-based cognitive training in people with Parkinson's disease: a route to transfer to everyday life
Open this publication in new window or tab >>The experience of process-based cognitive training in people with Parkinson's disease: a route to transfer to everyday life
2026 (English)In: Neuropsychological rehabilitation (Print), ISSN 0960-2011, E-ISSN 1464-0694, article id PMID 9112672Article in journal (Refereed) Epub ahead of print
Abstract [en]

Meta-analyses on cognitive training (CT) for people with Parkinson's Disease (PD) report improvements in global cognition and it is recommended as a treatment for people with PD with mild cognitive impairment. However, few studies have assessed the experience of CT. Therefore, this study explored the experience of process-based CT in people with PD and focused on how participants engaged with and made use of the training in their everyday life. In this study, semi-structured, individual interviews were conducted with 18 people with PD who had completed 6-8 weeks of process-based CT. Reflexive thematic analysis was used to analyse the data. Three overarching themes were developed that reported on the participants' (1) dedication towards CT; (2) meaning of seeing change in cognitive performance during CT; and (3) inspiration to transfer the knowledge, strategies and mindset from training into everyday life. Furthermore, a route to transfer was described including emotional and motivational experiences. In conclusion, CT was experienced in an active, reflective manner whereby emotional and cognitive challenges during training are dealt with and are seen as important ingredients to attain transfer to everyday life. Future studies are encouraged to examine the link between such qualitative findings and quantitatively measured outcomes.Trial registration: ClinicalTrials.gov identifier: NCT03680170..

Place, publisher, year, edition, pages
Routledge, 2026
Keywords
Cognitive training, Parkinson's disease, qualitative research, working memory
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:kau:diva-109011 (URN)10.1080/09602011.2026.2613961 (DOI)001686645200001 ()41667390 (PubMedID)2-s2.0-105029945906 (Scopus ID)
Available from: 2026-03-02 Created: 2026-03-02 Last updated: 2026-03-24Bibliographically approved

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