Open this publication in new window or tab >>2023 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 328, article id 115421Article in journal (Refereed) Published
Abstract [en]
Achieving symptomatic remission, as defined by the Remission in Schizophrenia Working Group, is intended tobe a meaningful outcome for individuals with schizophrenia, resulting in enhanced well-being. Cross-sectionalstudies have reported an association between symptomatic remission and subjective quality of life (QoL). Longitudinal studies aimed at examining this association have showed mixed results. The aim of this study was toexplore the relationship between symptomatic remission and subjective QoL, both cross-sectionally andlongitudinally. The study comprised data from what were at most 386 patients with schizophrenia, of whom 122–140 werefollowed over a period of four years. Based on cross-sectional remission status and longitudinal remissionpattern, differences in subjective QoL were explored. Remission status was assessed using the Positive andNegative Syndrome Scale (PANSS), and subjective QoL using the Short Form-36 Health Survey (SF-36). Both the cross-sectional and the longitudinal approach showed that patients in symptomatic remission hadsignificantly higher subjective QoL. Patients who were in non-remission at baseline, but who achieved remissionat follow-up, also had significantly higher subjective QoL at follow-up compared with baseline. The results from the study show a clear association between symptomatic remission and subjective QoL. However, achieving symptomatic remission does not appear to be a guarantee of sustained subjective QoL, andonly continued stable remission appears to result in such an outcome.
Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Longitudinal, Schizophrenia Spectrum Disorder, Subjective Quality of Life, Symptomatic Remission
National Category
Other Medical Sciences not elsewhere specified Psychiatry
Research subject
Psychology
Identifiers
urn:nbn:se:kau:diva-94294 (URN)10.1016/j.psychres.2023.115421 (DOI)001076677100001 ()37659163 (PubMedID)2-s2.0-85170063321 (Scopus ID)
Note
This paper was included as a manuscripts in Madeleine Johansson's doctoral thesis entitled 'Longitudinellt perspektiv på symtomatisk remission vid schizofreni' 2023:14.
2023-04-142023-04-142026-02-12Bibliographically approved