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  • 1. Abdel-Rehim, M.
    et al.
    Altun, Zeki
    Blomberg, Lars G
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    New trend in sample preparation: On-line microextraction in packed syringe (MEPS) for LC and GC applications, Part II, Determination of ropivacaine and its metabolites in human plasma samples using MEPS-LC-MS-MS2004In: J. Mass Spectr., 39 (2004) 1488-1493Article in journal (Refereed)
  • 2.
    Abdel-Rehim, Mohamed
    et al.
    AstraZeneca R&D Södertälje, Södertälje, Sweden.
    Andersson, L.I.
    AstraZeneca R&D Södertälje, Södertälje, Sweden.
    Altun, Zeki
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Blomberg, Lars G
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Microextraction in Packed Syringe Online with Liquid Chromatography-Tandem Mass Spectrometry: Molecularly imprinted polymer as packing material for MEPS in selective extraction of ropivacaine from plasma2006In: Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, E-ISSN 1520-572X, Vol. 29, no 12, p. 1725-1736Article in journal (Refereed)
    Abstract [en]

    The excellent performance of a new sample preparation method, microextraction in packed syringe (MEPS), was recently illustrated by online LC‐MS and GS‐MS assays of local anaesthetics in plasma samples. In the method, approximately 1 mg of solid packing material was inserted into a syringe (100–250 µL) as a plug. Sample preparation took place on the packed bed. The new method was easy to use, fully automated, of low cost, and rapid in comparison with previously used methods. This paper presents the use of molecularly imprinted polymers (MIPs) as packing material for higher extraction selectivity. Development and validation of a method for MIP‐MEPS online with LC‐MS‐MS using ropivacaine in plasma as model compound were investigated. A bupivacaine imprinted polymer was used. The method was validated and the standard curves were evaluated by means of quadratic regression and weighted by inverse of the concentration: 1/x for the calibration range 2–2000 nM. The applied polymer could be used more than 100 times before the syringe was discarded. The extraction recovery was 60%. The results showed high correlation coefficients (R 2 >0.999) for all runs. The accuracy, given as a percentage deviation from the nominal concentration values, ranged from -6% to 3%. The precision, given as the relative standard deviation, at three different concentrations (QC samples) was consistently about 3% to 10%. The limit of quantification was 2 nM.

  • 3. Altun, Zeki
    New Techniques for Sample Preparation in Analytical Chemistry: - Microextraction in Packed Syringe (MEPS) and Methacrylate Based Monolithic Pipette Tips2008Doctoral thesis, monograph (Other academic)
  • 4.
    Altun, Zeki
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    New Techniques for Sample Preparation in Analytical Chemistry: Microextraction in Packed Syringe (MEPS) and Methacrylate Based Monolithic Pipette Tips2008Doctoral thesis, comprehensive summary (Other scientific)
    Abstract [en]

    Sample preparation is often a bottleneck in systems for chemical analysis. The aim of this work was to investigate and develop new techniques to address some of the shortcomings of current sample preparation methods. The goal has been to provide full automation, on-line coupling to detection systems, short sample preparation times and high-throughput.

    In this work a new technique for sample preparation that can be connected on-line to liquid chromatography (LC) and gas chromatography (GC) has been developed. Microextraction in packed syringe (MEPS) is a new solid-phase extraction (SPE) technique that is miniaturized and can be fully automated. In MEPS approximately 1 mg of sorbent material is inserted into a gas tight syringe (100-250 μL) as a plug. Sample preparation takes place on the packed bed. Evaluation of the technique was done by the determination of local anaesthetics in human plasma samples using MEPS on-line with LC and tandem mass spectrometry (MS-MS). MEPS connected to an autosampler was fully automated and clean-up of the samples took about one minute. In addition, in the case of plasma samples the same plug of sorbent could be used for about 100 extractions before it was discarded.

    A further aim of this work was to increase sample preparation throughput. To do that disposable pipette tips were packed with a plug of porous polymer monoliths as sample adsorbent and were then used in connection with 96-well plates and LC-MS-MS. The evaluation of the methods was done by the analysis of local anaesthetics lidocaine and ropivacaine, and anti-cancer drug roscovitine in plasma samples. When roscovitine and lidocaine in human plasma and water samples were used as model substances, a 96-plate was handled in about two minutes. Further, disposable pipette tips may be produced at low cost and because they are used only once, carry-over is eliminated.

  • 5. Altun, Zeki
    et al.
    Abdel-Rehim, M.
    Blomberg, Lars G
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    New trends in sample preparation: On-line microextraction in packed syringe (MEPS) for LC and GC applications. Part III Determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent and MEPS-LC-MS-MS2004In: J. Chromatogr. B, 813 (2004) 129-135Article in journal (Refereed)
  • 6.
    Altun, Zeki
    et al.
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Andersson, Lars I.
    AstraZeneca R&D Södertälje, DMPK & BAC, Södertälje, Sweden.
    Blomberg, Lars G.
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Abdel-Rehim, Mohamed
    Karlstad University, Division for Business and Economics.
    Some Factors Affecting the Performance of Microextraction in Packed Syringe (MEPS)Manuscript (Other academic)
  • 7. Altun, Zeki
    et al.
    Blomberg, Lars G
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Use of carbon dioxide and ammonia as nebulizer gases in mass spectrometry2002In: Rapid Comm. Mass Spectrometry, 16 (2002) 738-739Article in journal (Refereed)
  • 8.
    Altun, Zeki
    et al.
    Karlstad University, Division for Chemistry.
    Blomberg, Lars G.
    Karlstad University, Division for Chemistry.
    Abdel-Rehim, Mohamed
    Karlstad University, Division for Chemistry.
    Increasing Sample Preparation Throughput Using Monolithic Methacrylate Polymer as Packing Material for 96-Tips: 2 Minutes per 96-Well Plate2005Manuscript (preprint) (Other academic)
  • 9. Altun, Zeki
    et al.
    Jagerdeo, E.
    Blomberg, Lars G
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Abdel-Rehim, M.
    Drug screening using microextraction in packed syringe (MEPS) / LC-MS utilizing monolithic-based sorbent material,2006In: Journal of Liquid Chromatography and Related Technologies, 29 (2006) 829-839Article in journal (Refereed)
  • 10.
    Blomberg, Lars G
    et al.
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Altun, Zeki
    New Techniques for Sample Preparation in Analytical Chemistry2005Licentiate thesis, monograph (Other academic)
  • 11.
    Blomberg, Lars G
    et al.
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Altun, Zeki
    Altun, Z.
    Abdel-Rehim, M.
    Increasing Sample Preparation Throughput Using Monolithic Methacrylate Polymer as Packing Material for 96-Tips2006In: J. Chromatogr. B, J. Liq. Chromatogr. & Rel. Technol., 29 (2006) 1725-1736Article in journal (Refereed)
  • 12.
    Blomberg, Lars G
    et al.
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Altun, Zeki
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
    Skoglund, C
    Abdel-Rehim, M
    Monolithic methacrylate packed 96-tips for high throughput bioanalysis2010In: Journal of Chromatography A, ISSN 0021-9673, Vol. 1217, no 16, p. 2581-2588Article in journal (Refereed)
1 - 12 of 12
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