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  • 1.
    Abdel-Rehim, Mohamed
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences. AstraZeneca R&D Sodertalje, Global DMPK, Sodertalje, Sweden.;Karlstad Univ, Fac Sci & Technol, Dept Chem & Biomed Sci, Karlstad, Sweden..
    On-Line Whole Blood Analysis Using Microextraction by Packed Sorbent and LC-MS-MS2011In: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 29, no 7, p. 612-618Article in journal (Refereed)
    Abstract [en]

    Microextraction by packed sorbent (MEPS) is a new technique for sample preparation that can be connected on-line with liquid chromatography (LC) or gas chromatography (GC) systems without any modifications. This article describes the use of MEPS in clinical and preclinical studies to quantify different drugs in whole blood samples. MEPS was used to determine cyclophosphamide in mouse blood from preclinical g studies using 20 mu L of blood samples. The interday accuracies and 0 precisions ranged from 107-109% and from 2.0-7.0%, respectively. The determination of four immunosuppressive drugs in human blood by MEPS and liquid chromatography-mass spectrometry (LC-MS) is described. The method showed a good selectivity and sensitivity. The calibration curves for everolimus, sirolimus, and tacrolimus ranged from 0.5 to 50 ng/mL and for cyclosporine from 3.0 to 1500 ng/mL. Intraday precisions for the studied immunosuppressive drugs were 2.0-11.7% and interday precision ranged from 5.1 to 13.7% (CV).

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