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  • 1.
    Hegazy, Mohamed-Elamir F.
    et al.
    Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Med Plants Dept, Giza 12622, Egypt..
    El-Beih, Ahmed A.
    Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt..
    Moustafa, Alaa Y.
    Sohag Univ, Dept Zool, Fac Sci, Sohag, Egypt..
    Hamdy, Abdelhamed A.
    Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt..
    Alhammady, Montaser A.
    Natl Inst Oceanog & Fisheries, Red Sea Branch, Hurghada, Egypt..
    Selim, Rehab M.
    Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt..
    Abdel-Rehim, Mohamed
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences. Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Karlstad Univ, Dept Chem & Biomed Sci, Fac Sci & Technol, SE-65188 Karlstad, Sweden.;Astra Zeneca, R&D, Dept Clin Pharmacol, S-15185 Sodertalje, Sweden.;Astra Zeneca, R&D, DMPK, S-15185 Sodertalje, Sweden..
    Pare, Paul W.
    Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA..
    Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum2011In: Natural Product Communications, ISSN 1934-578X, E-ISSN 1555-9475, Vol. 6, no 12, p. 1809-1812Article in journal (Refereed)
    Abstract [en]

    One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.

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