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  • 1.
    Ashri, Nadia Y.
    et al.
    Najd Consulting Hosp, Riyadh, Saudi Arabia..
    Abdel-Rehim, Mohamed
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences. AstraZeneca R&D Sodertalje, Clin Pharmacol, SE-15185 Sodertalje, Sweden.;AstraZeneca R&D Sodertalje, DMPK, SE-15185 Sodertalje, Sweden.;Karlstad Univ, Dept Chem & Biomed Sci, SE-65188 Karlstad, Sweden.;Stockholm Univ, Dept Analyt Chem, SE-10691 Stockholm, Sweden..
    Sample treatment based on extraction techniques in biological matrices2011In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 3, no 17, p. 2003-2018Article, review/survey (Refereed)
    Abstract [en]

    The importance of sample preparation methods as the first stage in bioanalysis is described. In this article, the sample preparation concept and strategies will be discussed, along with the requirements for good sample preparation. The most widely used sample preparation methods in the pharmaceutical industry are presented; for example, the need for same-day rotation of results from large numbers of biological samples in pharmaceutical industry makes high throughput bioanalysis more essential. In this article, high-throughput sample preparation techniques are presented; examples are given of the extraction and concentration of analytes from biological matrices, including protein precipitation, solid-phase extraction, liquid-liquid extraction and microextraction-related techniques. Finally, the potential role of selective extraction methods, including molecular imprinted phases, is considered.

  • 2.
    Said, Rana
    et al.
    Huddinge Univ Hosp, Dept Clin Pharmacol, S-17176 Stockholm, Sweden..
    Kamel, Mohamed
    Huddinge Univ Hosp, Dept Clin Pharmacol, S-17176 Stockholm, Sweden..
    El-Beqqali, Aziza
    Huddinge Univ Hosp, Dept Clin Pharmacol, S-17176 Stockholm, Sweden..
    Abdel-Rehim, Mohamed
    Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences. Karlstad Univ, Dept Chem & Biomed Sci, Fac Sci & Technol, S-65188 Karlstad, Sweden.;AstraZeneca R&D, Dept Clin Pharmacol, S-15185 Sodertalje, Sweden.;AstraZeneca R&D, DMPK, S-15185 Sodertalje, Sweden..
    Microextraction by packed sorbent for LC-MS/MS determination of drugs in whole blood samples2010In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 2, no 2, p. 197-205Article in journal (Refereed)
    Abstract [en]

    Background: Microextraction by packed sorbent (MEPS) is used as an online sample-preparation method. The determination of local anesthetics lidocaine, ropivacaine and bupivacaine directly in human blood was performed using MEPS online with LC-MS/MS. Results: The range of the calibration curves in whole blood was 10-10000 nmol/l. The lower limit of quantification was set to 10.0 nmol/l. The accuracy of the quality control samples ranged from 85 to 97%. The interday precision of the studied analytes was within the range 1-5%. The regression correlation coefficient (r(2)) was over 0.995 for all runs. The present method is rapid, reliable and robust and may be used for therapeutic drug monitoring of studied analytes in whole blood. Conclusion: This assay allows the analysis of drugs in human blood directly. Sample preparation is simple and automated. The assay reduced the handling time and the cost, and could handle small volumes of whole blood samples (25 mu l).

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