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  • 1.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.
    Phthalate exposure heralds birth defects2015In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 64, p. VI-VIArticle in journal (Other academic)
  • 2.
    Bornehag, Carl-Gustaf
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.
    Carlstedt, Fredrik
    Cty Council Varmland, Karlstad, Sweden..
    Jonsson, Bo A. G.
    Lund Univ, Div Occupat & Environm Med, Lund, Sweden..
    Lindh, Christian H.
    Lund Univ, Div Occupat & Environm Med, Lund, Sweden..
    Jensen, Tina K.
    Univ Southern Denmark, Dept Environm Med, Odense, Denmark..
    Bodin, Anna
    Cty Council Varmland, Karlstad, Sweden..
    Jonsson, Carin
    Cty Council Varmland, Karlstad, Sweden..
    Janson, Staffan
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.
    Swan, Shanna H.
    Icahn Sch Med Mt Sinai, New York, NY 10029 USA..
    Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys2015In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 123, no 1, p. 101-107Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The anogenital distance (AGD)-the distance from the anus to the genitals-has been used to assess reproductive toxicity. OBJECTIVE: The objective of this study was to examine the associations between prenatal phthalate exposure and AGD in Swedish infants. METHODS: AGD was measured in 196 boys at 21 months of age, and first-trimester urine was analyzed for 10 phthalate metabolites of DEP (diethyl phthalate), DBP (dibutyl phthalate), DEHP, BBzP (benzylbutyl phthalate), as well as DiNP and creatinine. Data on covariates were collected by questionnaires. RESULTS: The most significant associations were found between the shorter of two AGD measures (anoscrotal distance; AGDas) and DiNP metabolites and strongest for oh-MMeOP [mono(4-methyl-7-hydroxyloctyl) phthalate] and oxo-MMeOP [mono-(2-ethyl-5-oxohexyl) phthalate]. However, the AGDas reduction was small (4%) in relation to more than an interquartile range increase in DiNP exposure. CONCLUSIONS: These findings call into question the safety of substituting DiNP for DEHP in soft PVC, particularly because a shorter male AGD has been shown to relate to male genital birth defects in children and impaired reproductive function in adult males and the fact that human levels of DiNP are increasing globally.

  • 3.
    De Nardis, Luca
    et al.
    Sapienza Univ Rome, Italy.
    Caso, Giuseppe
    Ericsson Res, Kista, Sweden.
    Alay, Ozgu
    Univ Oslo, Norway.
    Ali, Usman
    Sapienza Univ Rome, Italy.
    Neri, Marco
    Rohde&Schwarz, Italy.
    Brunström, Anna
    Karlstad University, Faculty of Economic Sciences, Communication and IT (discontinued), Centre for HumanIT. Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Mathematics and Computer Science (from 2013).
    Di Benedetto, Maria-Gabriella
    Sapienza Univ Rome, Italy.
    Positioning by fingerprinting with multiple cells in NB-IoT networks2022In: / [ed] Nurmi, J; Lohan, ES; Sospedra, JT; Kuusniemi, H ; Ometov, A, Institute of Electrical and Electronics Engineers (IEEE), 2022Conference paper (Refereed)
    Abstract [en]

    Narrowband Internet of Things (NB-IoT) has quickly become a leading technology in the deployment of IoT systems and services, thanks to its appealing features in terms of coverage and energy efficiency, as well as compatibility with existing mobile networks. Increasingly, IoT services and applications require location information to be paired with data collected by devices; NB-IoT still lacks, however, reliable positioning methods. Time-based techniques inherited from Long Term Evolution (LTE) are not yet widely available in existing networks, and are expected to perform poorly on NB-IoT signals due to their narrow bandwidth. This investigation proposes a set of strategies for NB-IoT positioning, based on fingerprinting, that use coverage and radio information from multiple cells. The proposed strategies are evaluated on a large-scale dataset that includes experimental data from two NB-IoT operators. Results show that the proposed strategies, using a combination of coverage and radio information from multiple cells, outperform current state-of-the-art approaches based on single cell finger-printing, with a minimum average positioning error of about 20 meters, consistent across different network scenarios, vs. about 70 meters for current state-of-the-art. 

  • 4.
    Derakhshan, Arash
    et al.
    Academic Center for Thyroid Diseases, Netherlands.
    Shu, Huan
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Broeren, Maarten A.C.
    Máxima Medical Centre, Netherlands.
    Kortenkamp, Andreas
    Brunel University, United Kingdom.
    Lindh, Christian H.
    Lund University, Sweden.
    Demeneix, Barbara
    CNRS/Muséum National d'Histoire Naturelle, France.
    Peeters, Robin P.
    Academic Center for Thyroid Diseases, Netherlands.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, USA.
    Korevaar, Tim I.M.
    Academic Center for Thyroid Diseases, Netherlands.
    Association of endocrine disrupting chemicals exposure with human chorionic gonadotropin concentrations in pregnancy2023In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 178, article id 108091Article in journal (Refereed)
    Abstract [en]

    Background: Human chorionic gonadotropin (hCG) is produced by the placenta and plays an essential role in the maintenance of pregnancy. Endocrine disrupting chemicals (EDCs) have the potential to interfere with functions related to the production and secretion of hCG; however associations between exposure to EDCs and hCG concentrations in humans remain to be elucidated. Objectives: To investigate the association of urinary, serum and plasma concentrations of EDCs during pregnancy with serum hCG concentrations. Methods: We utilized data form the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. We investigated the association of 26 EDCs measured in early pregnancy urine or blood with serum hCG concentrations using multi-variable adjusted linear regression models per EDC and Weighted Quantile Sum (WQS) regression with repeated holdout validation for the EDCs mixture. Results: In 2,039 included women, higher exposure to bisphenol A was associated with lower hCG (beta [95% CI]: −0.06 [−0.11 to −0.002]) while higher triclosan exposure was associated with a higher hCG (0.02 [0.003 to 0.04]). Higher exposure to several phthalates, including mono-ethyl and mono-butyl phthalates (MEP and MBP) as well as metabolites of di-2-ethylhexyl phthalate (DEHP) was associated with a lower hCG (beta [95% CI] for sum of DEHP metabolites: −0.13 [−0.19 to −0.07]). Likewise, higher exposure to several polychlorinated biphenyls (PCBs) was associated with a lower hCG. In the WQS regression, each quartile increase in the EDCs mixture was associated with −0.27 lower hCG (95% CI: −0.34 to −0.19). Discussion: Higher exposure to several EDCs during pregnancy was associated with a lower hCG; and despite the small effect sizes, still indicating that the exposure may negatively affect production or secretion of hCG by the placenta. Our results provide the impetus for future experimental studies to investigate the placenta as a target organ for adverse effects of EDCs. 

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  • 5.
    Englund, Liselotte
    et al.
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Department of Political, Historical, Religious and Cultural Studies (from 2013). Uppsala University, Sweden.
    Bergh Johannesson, Kerstin
    Uppsala University, Sweden.
    Arnberg, Filip K.
    Uppsala University, Sweden.
    Reporting under extreme conditions: journalists' experience of disaster coverage2023In: Frontiers in Communication, E-ISSN 2297-900X, Vol. 8Article in journal (Refereed)
    Abstract [en]

    Introduction: Media presence on site and reports on disasters are crucial parts of disaster communication. Aside from authorities, civil society, concerned businesses and citizens, the media constitute an important actor. The working conditions, situational competence and management among journalists on duty in a disaster area are important factors within the complex area of crisis management and disaster communication. This study aims to explore the working conditions, challenges, and coping strategies among journalists covering the Haiti earthquake in 2010.

    Methods: Ten months after the event, Scandinavian journalists (n = 32) provided free-text responses about their work on site through a web survey. The free- text responses underwent content analysis. In addition, self-report questionnaires were used to assess general mental health and posttraumatic stress.

    Results: We found that journalists faced five main challenges in Haiti: situational (technicalities, practical, collegial), professional (mission, approach, roles), personal (traits, emotions, coping), traumatic (general mental health and posttraumatic stress) and experiential (learning and growth). They described a difficult and challenging mission, but also an eye-opening and life-changing experience. Most respondents' questionnaire responses indicated low risk for both poor mental health and posttraumatic stress, with a few significant exceptions. Being properly equipped and mentally prepared, getting collegial support and maintaining professional focus were seen as important, and good leadership and clear instructions from editors at home were highlighted.

    Discussion: Corroboration of the present findings would strengthen our knowledge of their experiences, and may provide valuable insights for designing preparedness activities in the future as well as for applying to other communication functions in disasters.

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    Englund et al 2023 Reporting under extreme conditions: journalists' experience of disaster coverage
  • 6. Eriksson, Andrea
    et al.
    Orvik, Arne
    Strandmark K, Margaretha
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Nordsteien, Anita
    Torp, Steffen
    Management and leadership approaches to health promotion and sustainable workplaces: A scoping review2017In: Societies, E-ISSN 2075-4698, Vol. 7, no 2, article id 14Article in journal (Refereed)
    Abstract [en]

    Whole-system approaches linking workplace health promotion to the development of a sustainable working life have been advocated. The aim of this scoping review was to map out if and how whole-system approaches to workplace health promotion with a focus on management, leadership, and economic efficiency have been used in Nordic health promotion research. In addition, we wanted to investigate, in depth, if and how management and/or leadership approaches related to sustainable workplaces are addressed. Eighty-three articles were included in an analysis of the studies' aims and content, research design, and country. For a further in-depth qualitative content analysis we excluded 63 articles in which management and/or leadership were only one of several factors studied. In the in-depth analysis of the 20 remaining studies, four main categories connected to sustainable workplaces emerged: studies including a whole system understanding; studies examining success factors for the implementation of workplace health promotion; studies using sustainability for framing the study; and studies highlighting health risks with an explicit economic focus. Aspects of sustainability were, in most articles, only included for framing the importance of the studies, and only few studies addressed aspects of sustainable workplaces from the perspective of a whole-system approach. Implications from this scoping review are that future Nordic workplace health promotion research needs to integrate health promotion and economic efficiency to a greater extent, in order to contribute to societal effectiveness and sustainability.

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  • 7.
    Grim, Katarina
    et al.
    Dalarna University.
    Rosenberg, David
    Umeå universitet, Institutionen för socialt arbete.
    Svedberg, Petra
    Schön, Ulla-Karin
    Shared decision-making in mental health care: a user perspective on decisional needs in community-based services2016In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 11, article id 30563Article in journal (Refereed)
    Abstract [en]

    Background: Shared decision-making (SDM) is an emergent research topic in the field of mental health care and is considered to be a central component of a recovery-oriented system. Despite the evidence suggesting the benefits of this change in the power relationship between users and practitioners, the method has not been widely implemented in clinical practice.

    Objective: The objective of this study was to investigate decisional and information needs among users with mental illness as a prerequisite for the development of a decision support tool aimed at supporting SDM in community-based mental health services in Sweden.

    Methods: Three semi-structured focus group interviews were conducted with 22 adult users with mental illness. The transcribed interviews were analyzed using a directed content analysis. This method was used to develop an in-depth understanding of the decisional process as well as to validate and conceptually extend Elwyn et al.’s model of SDM.

    Results: The model Elwyn et al. have created for SDM in somatic care fits well for mental health services, both in terms of process and content. However, the results also suggest an extension of the model because decisions related to mental illness are often complex and involve a number of life domains. Issues related to social context and individual recovery point to the need for a preparation phase focused on establishing cooperation and mutual understanding as well as a clear follow-up phase that allows for feedback and adjustments to the decision-making process.

    Conclusions and Implications for Practice: The current study contributes to a deeper understanding of decisional and information needs among users of community-based mental health services that may reduce barriers to participation in decision-making. The results also shed light on attitudinal, relationship-based, and cognitive factors that are important to consider in adapting SDM in the mental health system. 

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  • 8.
    Gunn, Virginia
    et al.
    Karolinska Institutet ; Michaels Hospital, CAN;University of Toronto, CAN.
    Kreshpaj, Bertina
    Karolinska institutet.
    Matilla-Santander, Nuria
    Karolinska institutet.
    Vignola, Emilia F.
    CUNY, Department of Community Health and Social Sciences, USA..
    Wegman, David H.
    University Massachusetts Lowell, USA ;La Isla Network, USA..
    Hogstedt, Christer
    Karolinska Institutet.
    Ahonen, Emily Q.
    University Utah, USA..
    Bodin, Theo
    Karolinska Institutet;Stockholm Region.
    Orellana, Cecilia
    Karolinska Institutet.
    Baron, Sherry
    CUNY Queens College, USA..
    Muntaner, Carles
    University of Toronto, CAN;Johns Hopkins University, USA.
    O'Campo, Patricia
    Michaels Hospital, CAn ;University Toronto, CAN .
    Albin, Maria
    Karolinska Institutet;Stockholm Region.
    Håkansta, Carin
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013). Karolinska Institutet .
    Initiatives Addressing Precarious Employment and Its Effects on Workers' Health and Well-Being: A Systematic Review2022In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 19, no 4, article id 2232Article, review/survey (Refereed)
    Abstract [en]

    The prevalence of precarious employment has increased in recent decades and aspects such as employment insecurity and income inadequacy have intensified during the COVID-19 pandemic. The purpose of this systematic review was to identify, appraise, and synthesise existing evidence pertaining to implemented initiatives addressing precarious employment that have evaluated and reported health and well-being outcomes. We used the PRISMA framework to guide this review and identified 11 relevant initiatives through searches in PubMed, Scopus, Web of Science, and three sources of grey literature. We found very few evaluated interventions addressing precarious employment and its impact on the health and well-being of workers globally. Ten out of 11 initiatives were not purposefully designed to address precarious employment in general, nor specific dimensions of it. Seven out of 11 initiatives evaluated outcomes related to the occupational health and safety of precariously employed workers and six out of 11 evaluated worker health and well-being outcomes. Most initiatives showed the potential to improve the health of workers, although the evaluation component was often described with less detail than the initiative itself. Given the heterogeneity of the 11 initiatives regarding study design, sample size, implementation, evaluation, economic and political contexts, and target population, we found insufficient evidence to compare outcomes across types of initiatives, generalize findings, or make specific recommendations for the adoption of initiatives.

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  • 9.
    Koch, Holger M.
    et al.
    Inst Prevent & Occupat Med German Social Accid In, Bochum.
    Lessmann, Frederik
    Univ Med Ctr Hamburg .
    Swan, Shanna H.
    Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlthh New York.
    Hauser, Russ
    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston.
    Kolossa-Gehring, Marike
    German Environm Agcy UBA, Berlin,.
    Frederiksen, Hanne
    Univ Copenhagen, Rigshosp Dept Growth & Reprod, Copenhagen.
    Andersson, Anna-Maria
    Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen.
    Thomsen, Cathrine
    Norwegian Inst Publ Hlth, Dept Environm Exposure & Epidemiol, Oslo, Norway.
    Sakhi, Amrit K.
    Norwegian Inst Publ Hlth, Dept Environm Exposure & Epidemiol, Oslo, Norway Norwegian Inst Publ Hlth, Dept Environm Exposure & Epidemiol, Oslo, Norway.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York,.
    Mueller, Jochen F.
    Univ Queensland, Queensland Alliance Environm Hlth Sci, Brisbane.
    Rudel, Ruthann A.
    Silent Spring Inst, Newton.
    Braun, Joseph M.
    Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence.
    Harth, Volker
    Univ Med Ctr Hamburg Eppendorf UKE.
    Bruening, Thomas
    Inst Ruhr Univ Bochum IPA, Inst Prevent & Occupat Med German Social Accid In, Bochum.
    Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme2018In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1100, p. 91-92Article in journal (Refereed)
  • 10.
    Kreshpaj, Bertina
    et al.
    Karolinska Institutet.
    Bottai, Matteo
    Karolinska Institutet.
    Matilla-Santander, Nuria
    Karolinska Institutet.
    Axén, Magnus
    Uppsala universitet.
    Orellana, Cecilia
    Karolinska Institutet.
    Burström, Bo
    Karolinska Institutet.
    Hemmingsson, Tomas
    Karolinska Institutet; Stockholms universitet.
    Jonsson, Johanna
    Karolinska Institutet.
    Håkansta, Carin
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013). Karolinska Institutet.
    Wegman, David H.
    University of Massachusetts Lowell, USA.
    Bodin, Theo
    Karolinska Institutet; Stockholm County Council.
    Business performance and occupational injuries trajectories in the construction sector in Sweden2022In: Safety Science, ISSN 0925-7535, E-ISSN 1879-1042, Vol. 152, article id 105772Article in journal (Refereed)
    Abstract [en]

    Objective: To identify patterns in business performance and occupational injuries (OIs) in the Swedish construction sector between 2003 and 2015 and investigate associations between these trajectories. Methods: Company-level data were gathered from national registers. An open cohort of 13,089 private construction companies were classified by size. Yearly business performance indicators were return on equity, operating margin, and labor-to-revenue ratio. OIs rate was defined as number of injuries divided by number of employees. Group-based trajectory models were performed to identify companies with similar patterns in business performance and OIs rate over time. Associations were investigated with binomial regression models. Results: The model identified two main patterns (high/low) of injuries and business indicators for all company sizes. Trends in low labor-to-revenue ratio were associated with a high injury rate with a pooled estimate of 1.43 (95% CI 1.22–1.64) with some variation by company size: super small OR 1.3 (95% CI 1.01–1.62), small, OR 1.74 (95% CI 1.39–2.18), medium OR 1.3 (95% CI 0.9–1.8) and large OR 2.1 (95% CI 0.77–5.7). Similarly, low patterns of returns on equity were associated with high injury rate patterns across all company sizes, excluding small enterprises. No associations were found for operating margin patterns. Conclusions: Low returns on equity and labor-to-revenue ratio were associated with higher OIs rate trajectories in the Swedish construction sector, which has implications for injury prevention as well as targeted surveillance and inspection. Further studies could investigate other economic sectors and possible mechanisms for this association.

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  • 11.
    Kreshpaj, Bertina
    et al.
    Karolinska Institutet; University of Copenhagen, DNK.
    Wegman, David H.
    University of Massachusetts Lowell, USA.
    Burström, Bo
    Karolinska Institutet.
    Davis, Letitia
    Massachusetts Department of Public Health, USA.
    Hemmingsson, Tomas
    Karolinska Institutet.
    Håkansta, Carin
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013). Karolinska Institutet.
    Jonsson, Johanna
    Karolinska Institutet.
    Johansson, Gun
    Karolinska Institutet; Stockholms Läns Landsting.
    Kjellberg, Katarina
    Karolinska Institutet; Stockholms Läns Landsting.
    Martinez, Nestor Sanchez
    Karolinska Institutet.
    Matilla-Santander, Nuria
    Karolinska Institutet.
    Orellana, Cecilia
    Karolinska institutet.
    Bodin, Theo
    Karolinska Institutet; Stockholms Läns Landsting.
    Precarious employment and occupational injuries in Sweden between 2006 and 2014: a register-based study2023In: Occupational and Environmental Medicine, ISSN 1351-0711, E-ISSN 1470-7926, Vol. 80, p. 179-185Article in journal (Refereed)
    Abstract [en]

    BackgroundPrecarious employment (PE) has been suggested as a risk factor for occupational injuries (OIs). However, several issues such as under-reporting and time at risk pose obstacles to obtaining unbiased estimates of risk ObjectiveTo investigate if PE is a risk factor for OIs in Sweden. MethodsThis register-based study included employed workers aged 18-65, resident in Sweden between 2006 and 2014. PE was operationalised as a multidimensional construct (score) and by its five items (contract insecurity, contractual temporariness, multiple jobs/multiple sectors, income level, collective bargaining agreement). Our outcome was OI in the following year. Pooled ORs for OIs in relation to PE and PE items were calculated by means of multivariate logistic regression models for women and men separately. ResultsPrecarious workers were at lower risk of OIs as compared with non-precarious workers among both males and females (OR <1) also when applying weights for under-reporting and adjusting for time at risk (part-time work). Male agencies workers had a higher risk of OIs (OR 1.19, 95% CI 1.15 to 1.23), as did male and female workers in multiple jobs/sectors (OR 1.25, 95% CI 1.23 to 1.28 and OR 1.10, 95% CI 1.07 to 1.13 respectively), and female workers in the low-income groups (OR 1.11, 95% CI 1.09 to 1.12). Low coverage of collective bargaining agreements was associated with a lower risk of OIs for both men and women (OR 0.30, 95% CI 0.29 to 0.31 and OR 0.26, 95% CI 0.24 to 0.27, respectively). ConclusionsWhile several mechanisms may explain why precarious workers in Sweden present lower risks of OIs, several dimensions of PE such as temp agency work and multiple job-holding could be important risk factors for OIs and merit further research.

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  • 12.
    Kvart, Signild
    et al.
    Karolinska Institutet.
    Jonsson, Johanna
    Karolinska Institutet.
    Bodin, Theo
    Karolinska Institutet ; Stockholm Region.
    Håkansta, Carin
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013). Karolinska Institutet.
    Kreshpaj, Bertina
    Karolinska Institutet.
    Orellana, Cecilia
    Karolinska Institutet.
    Östergren, Per-Olof
    Lund University.
    Nylen, Lotta
    Karolinska institutet ; Stockholm Region.
    Matilla-Santander, Nuria
    Karolinska Institutet.
    Precarious Employment and Psychosocial Hazards: A Cross-Sectional Study in Stockholm County2021In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 18, no 21, article id 11218Article in journal (Refereed)
    Abstract [en]

    Precarious employment (PE) has been linked to adverse health effects, possibly mediated through psychosocial hazards. The aim of this cross-sectional study is to explore if higher levels of PE are associated with psychosocial hazards (experiences of violence, sexual harassment, bullying, discrimination, high demands, and low control) and to explore gender differences in these patterns. The study is based on survey- and register data from a sample of 401 non-standard employees in Stockholm County (2016-2017). The level of PE (low/high) was assessed with the Swedish version of the employment precariousness scale (EPRES-Se) and analysed in relation to psychosocial hazards by means of generalized linear models, with the Poisson family and robust variances. After controlling for potential confounders (gender, age, country of birth, and education), the prevalence of suffering bullying (PR 1.07, 95% CI: 1.01-1.13) and discrimination (PR 1.52, 95% CI: 1.00-2.32) was higher among individuals with a high level of PE. Regarding the demand/control variables, a high level of PE was also associated with low control (PR 1.59, 95% CI: 1.30-1.96) and passive work (the combination of low demands and low control) (PR 1.60, 95% CI: 1.23-2.08). Our findings suggest that workers in PE are more likely to experience psychosocial hazards, and these experiences are more prevalent among women compared to men. Future longitudinal studies should look further into these associations and their implications for health and health inequalities.

  • 13.
    Levin-Schwartz, Yuri
    et al.
    Icahn School of Medicine at Mount Sinai, USA.
    Curtin, Paul
    Icahn School of Medicine at Mount Sinai, USA.
    Flores, Daniel
    Icahn School of Medicine at Mount Sinai, USA.
    Aushev, Vasily N.
    Icahn School of Medicine at Mount Sinai, USA.
    Tamayo-Ortiz, Marcela
    National Council for Science & Technology, MEX; National Institute of Public Health, MEX.
    Svensson, Katherine
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Pantic, Ivan
    National Institute of Perinatology, MEX.
    Estrada-Gutierrez, Guadalupe
    National Institute of Perinatology, MEX.
    Pizano-Zarate, Maria L.
    National Institute of Perinatology, MEX.
    Gennings, Chris
    Icahn School of Medicine at Mount Sinai, USA.
    Satlin, Lisa M.
    Icahn School of Medicine at Mount Sinai, USA.
    Baccarelli, Andrea A.
    Columbia University, USA.
    Tellez-Rojo, Martha M.
    National Institute of Public Health, MEX.
    Wright, Robert O.
    Icahn School of Medicine at Mount Sinai, USA.
    Sanders, Alison P.
    Icahn School of Medicine at Mount Sinai, USA.
    Exosomal miRNAs in urine associated with children's cardiorenal parameters: A cross-sectional study2021In: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308, Vol. 13, no 7, p. 499-512Article in journal (Refereed)
    Abstract [en]

    Aims: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. Materials & Methods: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4-6 years. The authors measured associations between 193 exo-miRs and cardiorenal outcomes: systolic/diastolic blood pressure, estimated glomerular filtration rate and urinary sodium and potassium levels. The authors adjusted for age, sex, BMI, socioeconomic status, indoor tobacco smoke exposure and urine specific gravity. Results: Multiple exo-miRs were identified meeting a false discovery rate threshold of q < 0.1. Specifically, three exo-miRs had increased expression with urinary sodium, 17 with urinary sodium-to-potassium ratio and one with decreased estimated glomerular filtration rate. Conclusions: These results highlight urinary exo-miRs as early-life biomarkers of children's cardiorenal health.

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  • 14.
    Nidens, N.
    et al.
    University Leipzig, DEU.
    Krönke, A.
    University Leipzig, DEU.
    Jurkutat, A.
    University Leipzig, DEU.
    Schlingmann, M.
    University Leipzig, DEU.
    Poulain, T.
    University Leipzig, DEU.
    Nüchter, M.
    University Leipzig, DEU.
    Kiviranta, H.
    Finnish Institute for Health and Welfare (THL), FIN.
    Körner, A.
    University Leipzig, DEU ; University Leipzig, DEU.
    Vogel, M.
    University Leipzig, DEU.
    Lindh, C.
    Lund University.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn Sch Med Mt Sinai, USA.
    Kiess, W.
    University Leipzig, DEU.
    Associations of prenatal exposure to phthalates and one phthalate substitute with anthropometric measures in early life: Results from the German LIFE Child cohort study2021In: Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism, ISSN 1521-690X, E-ISSN 1532-1908, Vol. 35, no 5, article id 101532Article in journal (Refereed)
    Abstract [en]

    Exposure to phthalates is widespread and especially early life stages represent a critical window of exposure. In the present study, we investigated the effect of prenatal exposure to phthalates on birth outcomes and weight development in early life. In 130 mother–child pairs, we estimated the association of concentrations of 13 phthalates in spot-urine samples collected during pregnancy and birth outcomes and weight gain in the first two years of life using robust linear regression. High molecular weight phthalates were inversely associated with birth weight in girls but not in boys. Thus, prenatal exposure to phthalates may affect birth weight in a sex-specific manner.

  • 15.
    Nilson, Finn
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Centre for Public Safety (from 2013).
    Lindberg, Fredrik
    Göteborgs universitet.
    Palm, Gunnar
    Göteborgs universitet.
    Lundgren, Linnea
    Ersta Skondal.
    Rayner, David
    Göteborgs universitet.
    Börjesson, Mats
    Göteborgs universitet.
    Thorsson, Sofia
    Göteborgs universitet.
    Khorram-Manesh, Amir
    Göteborgs universitet.
    Carlström, Eric
    Göteborgs universitet.
    Testing a novel method for identifying where serious medical encounters occur at marathons in order to improve medical preparedness and runners’ safety2018In: Injury Prevention, ISSN 1353-8047, E-ISSN 1475-5785, Vol. 24, p. A29-A29Article in journal (Refereed)
  • 16.
    Palm, Kristina
    et al.
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013). Karolinska Institutet;KTH Royal Institute of Technology.
    Bergman, Ann
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013).
    Rosengren, Calle
    Lund University.
    Towards More Proactive Sustainable Human Resource Management Practices?: A Study on Stress Due to the ICT-Mediated Integration of Work and Private Life2020In: Sustainability, E-ISSN 2071-1050, Vol. 12, no 20, article id 8303Article in journal (Refereed)
    Abstract [en]

    This article discusses sustainability in Human Resource Management (HRM) in the blurred digital working life, focusing on the emotion of stress. Its empirical basis is an activity and emotion diary study conducted with 26 employees of three industrial companies in Sweden. Our results show that work and private life are integrated by digital activities and also by emotions. Due to the extensive use of digital devices, stress in the working sphere is not only connected with work, and stress in the private sphere is not only connected with private life. The study also shows that stress is often episodic and can end due to activities connected with both the trigger and non-trigger spheres. From a social sustainability perspective, this study suggests that HRM should gently extend employee consideration beyond the traditional temporal and spatial boundaries of work, i.e., also including private life when understanding work in the digital age.

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  • 17.
    Preece, Anna-Sofia
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Shu, Huan
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, USA.
    The Full Chain Model: Linking Chemical Exposure from Indoor Sources to Human Health Effects2022In: Handbook of Indoor Air Quality / [ed] Yinping Zhang, Philip K. Hopke, Corinne Mandin, Springer, 2022, 1, p. 1301-1324Chapter in book (Other academic)
    Abstract [en]

    There is an increasing concern for health risks from exposure to chemical emissions in indoor environments where we spend a lot of time. A chain of complex relationships connects emission sources, exposure, and health effects. For some indoor contaminants, we know a lot about the separate relationships. However, linking specific sources and environmental exposure pathways to hazardous effects is challenging, with a lack of evidence that is needed for risk assessment as a result. This chapter presents the full chain model that follows chemicals and maps the relationships from sources to potential health effects. It is a tool to establish relevant scientific knowledge regarding chemical exposure. The model consists of three overlapping sections: environmental exposure, human exposure, and health effects, and includes relationships between emission sources, environmental pathways, human uptake, and effects on health and development. As a demonstration, results from the Swedish Environmental Longitudinal Mother and child Asthma and allergy (SELMA) study were applied to the full chain model. Phthalates, a group of abundant indoor contaminants, and airway disorders were used as an example. Starting with polyvinyl chloride (PVC) flooring as an emission source, connections were made between indoor dust levels, exposure and uptake among pregnant women, and airway symptoms in young children. By using the full chain model, not only separate relationships were identified. Butylbenzyl phthalate could be followed from a source to elevated environmental exposure and human uptake to associations with a higher risk for airway outcomes in children. 

  • 18.
    Sapounidou, Maria
    et al.
    Umeå universitet, Sverige.
    Andersson, Patrik L.
    Umeå universitet, Sverige.
    Leemans, Michelle
    Sorbonne Université, France.
    Fini, Jean-Baptiste
    Sorbonne Université, France.
    Demeneix, Barbara
    Sorbonne Université, France.
    Rüegg, Joëlle
    Uppsala universitet, Sverige.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, USA.
    Gennings, Chris
    Icahn School of Medicine at Mount Sinai, USA.
    From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data2023In: Toxics, E-ISSN 2305-6304, Vol. 11, no 4, article id 331Article in journal (Refereed)
    Abstract [en]

    Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in children in a Swedish pregnancy cohort. A novel approach was proposed linking this epidemiological association with experimental evidence, where the effect of MIX N on thyroid hormone signaling was assessed using the Xenopus eleuthero-embryonic thyroid assay (XETA OECD TG248). From this experimental data, a point of departure (PoD) was derived based on OECD guidance. Our aim in the current study was to use updated toxicokinetic models to compare exposures of women of reproductive age in the US population to MIX N using a Similar Mixture Approach (SMACH). Based on our findings, 66% of women of reproductive age in the US (roughly 38 million women) had exposures sufficiently similar to MIX N. For this subset, a Similar Mixture Risk Index (SMRIHI) was calculated comparing their exposures to the PoD. Women with SMRIHI &gt; 1 represent 1.1 million women of reproductive age. Older women, Mexican American and other/multi race women were less likely to have high SMRIHI values compared to Non-Hispanic White women. These findings indicate that a reference mixture of chemicals identified in a Swedish cohort—and tested in an experimental model for establishment of (PoDs)—is also of health relevance in a US population. 

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  • 19.
    Soomro, Munawar Hussain
    et al.
    Sorbonne University, FRA ;St AntoiInst Desbrest Epidemiol & Sante Publ IDESP, FRA; University Montpellier, FRA; SMBB Medical University, PAK.
    Maesano, Cara Nichole
    Sorbonne University, FRA ;St Antoine Medical School, FRA.
    Heude, Barbara
    INSERM, UMR, FRA; Descartes University, Paris, FRA.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn Sch Med Mt Sinai, USA.
    Annesi-Maesano, Isabella
    The Desbrest Institute of Epidemiology and Public Health (IDESP), FRA; University Montpellier, FRA.
    The association between maternal urinary phthalate metabolites concentrations and pregnancy induced hypertension: Results from the EDEN Mother-Child Cohort2021In: Journal of gynecology obstetrics and human reproduction, ISSN 2468-7847, Vol. 50, no 10, article id 102216Article in journal (Refereed)
    Abstract [en]

    Background: Studies have suggested that exposure to endocrine disruptors such as phthalates that are widely used in our daily life (food wrapping, cosmetics, toys, medical devices, polyvinyl chloride flooring, and building materials) might be related to raised blood pressure and increased risk of cardiovascular diseases. Phthalates might induce a pro-inflammatory response and increased oxidative stress and may be a cause of pregnancy induced hypertension. Methods: We evaluated the association between maternal exposure to phthalates during pregnancy and pregnancy induced hypertension. 604 pregnant women were included and eleven phthalate metabolites were quantified in spot maternal urine samples collected between the 23rd and 28th week of gestation in a French EDEN mother-child cohort. The associations were assessed by applying multiple logistic regression analysis. Results: Twenty nine (4,8%) mothers developed pregnancy induced hypertension. Two low molecular weight phthalate metabolites: Monoethyl phthalate (MEP) and Mono-n-butyl phthalate (MBP) were positively associated with pregnancy induced hypertension in crude (Odds Ratio: 1.43, 95% Confidence Interval: 1.04-1.96, p-value = 0.02 and 1.48, 1.10-2.01, p-value =0.01) and in adjusted (1.47, 1.01-2.14, p-value = 0.04 and 1.66, 1.11-2.47, p-value = 0.01) models respectively. Conclusion: Our data suggest that prenatal exposure to some phthalates, including MEP and MBP, might play a role in pregnancy induced hypertension. (C) 2021 Elsevier Masson SAS. All rights reserved.

  • 20.
    Strandmark K, Margaretha
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Rahm, GullBritt
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Wilde-Larsson, Bodil
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Nordström, Gun
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Rystedt, Ingrid
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Preventive Strategies and Processes to Counteract Bullying in Health Care Settings: Focus Group Discussions.2016In: Issues in Mental Health Nursing, ISSN 0161-2840, E-ISSN 1096-4673, Vol. 38, no 2, p. 113-121Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to explore preventive strategies and processes to counteract bullying in workplaces. Data were collected by individual interviews and focus group discussions at one hospital and two nursing home wards for elderly, a total of 29 participants. In the analysis of the interviews we were inspired by constructivist grounded theory. Persistent work with a humanistic value system by supervisor and coworkers, raising awareness about the bullying problem, strong group collaboration, and conflict management, along with an open atmosphere at the workplace, appears to be imperative for accomplishing a policy of zero tolerance for bullying.

  • 21.
    Störe, Siri Jakobsson
    et al.
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Department of Social and Psychological Studies (from 2013).
    Tillfors, Maria
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Department of Social and Psychological Studies (from 2013).
    Angelhoff, Charlotte
    Crown Princess Victoria's Child and Youth Hospital, Sweden; Linköping University, Sweden.
    Norell-Clarke, Annika
    Kristianstad University, Sweden; Örebro University, Sweden.
    A robot intervention for adults with ADHD and insomnia-A mixed-method proof-of-concept study2023In: PLOS ONE, E-ISSN 1932-6203, Vol. 18, no 9, p. 1-20, article id e0290984Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To investigate individual effects of a three-week sleep robot intervention in adults with ADHD and insomnia, and to explore participants’ experiences with the intervention. METHODS: A proof-of-concept study with a mixed-methods design (n = 6, female = 4) where a repeated ABA single-case study was combined with interviews. Data were collected with the Consensus Sleep Diary, wrist actigraphy, questionnaires on symptoms of insomnia, arousal, emotional distress, and ADHD, and through individual interviews. RESULTS: Visual analysis of the sleep diary and actigraphy variables did not support any effects from the robot intervention. Half of participants reported clinically relevant reductions on the Insomnia Severity Index from pre- to post-intervention. No changes regarding ADHD or arousal. Thematic analysis of the interviews resulted in three themes: (1) A pleasant companion, (2) Too much/not enough, and (3) A new routine. CONCLUSION: Adjustments of the intervention ought to be made to match the needs of patients with both ADHD and insomnia before the next trial is conducted.

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  • 22.
    Svensson, Katherine
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Gennings, Chris
    Icahn School of Medicine at Mount Sinai, USA.
    Lindh, Christian
    Lund University, Sweden.
    Kiviranta, Hannu
    Finnish Institute for Health and Welfare, Finland.
    Rantakokko, Panu
    Finnish Institute for Health and Welfare, Finland.
    Wikström, Sverre
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). County Council of Värmland, Sweden; Örebro University, Sweden.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, USA.
    Prenatal exposures to mixtures of endocrine disrupting chemicals and sex-specific associations with children’s BMI and overweight at 5.5 years of age in the SELMA study2023In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 179, article id 108176Article in journal (Refereed)
    Abstract [en]

    Background: Prenatal exposure to mixtures of endocrine disrupting chemicals (EDC) has the potential to disrupt human metabolism. Prenatal periods are especially sensitive as many developmental processes are regulated by hormones. Prenatal exposure to EDCs has inconsistently been associated with children’s body mass index (BMI) and obesity. The objective of this study was to investigate if prenatal exposure to a mixture of EDCs was associated with children’s BMI and overweight (ISO-BMI ≥ 25) at 5.5 years of age, and if there were sex-specific effects. Methods: A total of 1,105 mother–child pairs with complete data on prenatal EDCs concentrations (e.g., phthalates, non-phthalate plasticizers, phenols, PAH, pesticides, PFAS, organochlorine pesticides, and PCBs), children’s measured height and weight, and selected covariates in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study were included in this analysis. The mixture effect of EDCs with children’s BMI and overweight was assessed using WQS regression with 100 repeated holdouts. A positively associated WQS index with higher BMI and odds of overweight was derived. Models with interaction term and stratified weights by sex was applied in order to evaluate sex-specific associations. Results: A significant WQS*sex interaction term was identified and associations for boys and girls were in opposite directions. Higher prenatal exposure to a mixture of EDCs was associated with lower BMI (Mean β = -0.19, 95%CI: −0.40, 0.01) and lower odds of overweight (Mean OR = 0.72, 95%CI: 0.48, 1.04) among girls with borderline significance. However, the association among boys did not reach statistical significance. Among girls, the possible chemicals of concern were MEP, 2-OHPH, BPF, BPS, DPP and PFNA. Conclusion: Prenatal exposure to a mixture of EDCs was associated with lower BMI and overweight among girls, and non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.

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  • 23.
    Tanner, Eva M
    et al.
    Icahn School of Medicine at Mount Sinai, United States.
    Unenge Hallerbäck, Maria
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Wikström, Sverre
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Örebro Universitet.
    Lindh, Christian
    Lunds Universitet.
    Kiviranta, Hannu
    National Institute for Health and Welfare, Finland.
    Gennings, Chris
    Icahn School of Medicine at Mount Sinai, United States.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, United States.
    Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven2020In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 134, p. 1-11, article id 105185Article in journal (Refereed)
    Abstract [en]

    Background: Endocrine disrupting chemicals (EDCs) are xenobiotics with the ability to interfere with hormone action, even at low levels. Prior environmental epidemiology studies link numerous suspected EDCs, including phthalates and bisphenol A (BPA), to adverse neurodevelopmental outcomes. However, results for some chemicals were inconsistent and most assessed one chemical at a time.

    Objectives: To evaluate the overall impact of prenatal exposure to an EDC mixture on neurodevelopment in school-aged children, and identify chemicals of concern while accounting for co-exposures.

    Methods: Among 718 mother-child pairs from the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (SELMA) study, we used Weighted Quantile Sum (WQS) regression to assess the association between 26 EDCs measured in 1st trimester urine or blood, with Wechsler Intelligence Scale for Children (IV) Intelligence Quotient (IQ) scores at age 7 years. Models were adjusted for child sex, gestational age, mother's education, mother's IQ (RAVEN), weight, and smoking status. To evaluate generalizability, we conducted repeated holdout validation, a machine learning technique.ResultsUsing repeated holdout validation, IQ scores were 1.9-points (CI = −3.6, −0.2) lower among boys for an inter-quartile-range (IQR) change in the WQS index. BPF made the largest contribution to the index with a weight of 14%. Other chemicals of concern and their weights included PBA (9%), TCP (9%), MEP (6%), MBzP (4%), PFOA (6%), PFOS (5%), PFHxS (4%), Triclosan (5%), and BPA (4%). While we did observe an inverse association between EDCs and IQ among all children when training and testing the WQS index estimate on the full dataset, these results were not robust to repeated holdout validation.

    Conclusion: Among boys, early prenatal exposure to EDCs was associated with lower intellectual functioning at age 7. We identified bisphenol F as the primary chemical of concern, suggesting that the BPA replacement compound may not be any safer for children. Future studies are needed to confirm the potential neurotoxicity of replacement analogues.

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  • 24.
    Wikström, Sverre
    et al.
    Örebro universitet.
    Lin, Ping-I
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Lindh, Christian H.
    Lunds universitet.
    Shu, Huan
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Stockholms universitet.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
    Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight2020In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 87, no 6, p. 1093-1099Article in journal (Refereed)
    Abstract [en]

    Background: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. Results: Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93–142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. Conclusions: We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

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  • 25.
    Wu, Haotian
    et al.
    Columbia University, USA.
    Kioumourtzoglou, Marianthi-Anna
    Columbia University, USA.
    Just, Allan C.
    Icahn School of Medicine at Mount Sinai, USA.
    Kloog, Itai
    Ben Gurion University, ISR.
    Sanders, Alison
    Icahn School of Medicine at Mount Sinai, USA.
    Svensson, Katherine
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    McRae, Nia
    Icahn School of Medicine at Mount Sinai, USA.
    Tamayo-Ortiz, Marcela
    Ministry Health, National Institute of Public Health, MEX ;Mexican Council of Science & Technology, MEX.
    Solano-Gonzalez, Maritsa
    Ministry Health, National Institute of Public Health, MEX.
    Wright, Robert O.
    Icahn School of Medicine at Mount Sinai, USA.
    Tellez-Rojo, Martha M.
    Ministry Health, National Institute of Public Health, MEX.
    Baccarelli, Andrea A.
    Columbia University, USA.
    Association of ambient PM2.5 exposure with maternal bone strength in pregnant women from Mexico City: a longitudinal cohort study2020In: The Lancet Planetary Health, E-ISSN 2542-5196, Vol. 4, no 11, p. E530-E537Article in journal (Refereed)
    Abstract [en]

    Background Pregnancy is associated with deteriorations in maternal bone strength and heightened susceptibility to bone fractures. We aimed to investigate whether ambient particulate matter (PM)(2.5) concentrations were associated with bone strength during pregnancy. Methods In this longitudinal cohort study, we analysed longitudinal data from women participating in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort in Mexico City, Mexico. Eligible women were aged 18 years or older, at less than 20 weeks' gestation at the time of recruitment, planning to stay in Mexico City for the next 3 years, without heart or kidney disease, did not use steroids or anti-epileptic drugs, were not daily consumers of alcohol, and had access to a telephone. Daily ambient PM2.5 concentrations were estimated from a spatio-temporal model that was based on the individual's address. Trabecular bone strength was measured using quantitative ultrasound from the radius of the middle finger and cortical bone strength from the proximal phalanx of the middle finger, during the second trimester, third trimester, and 1 and 6 months post partum. Bone strength T scores were modelled with PM2.5 concentrations using linear mixed models and distributed lag models. Findings Adjusting for multiple exposure windows, each 10 mu g/m(3) increase in PM2.5 exposure concentrations in the first trimester was associated with a 0.18 SD decrease (95% CI -0.35 to -0.01; p=0.033) in ultrasound speed-of-sound (SOS) T score of trabecular bone strength from the second trimester until 6 months post partum. Similarly, each 10 mu g/m(3) increase in third trimester PM2.5 exposure was associated with a 0.18 SD decrease (-0.36 to -0.01; p=0.044) in the SOS T score of trabecular bone strength from the third trimester until 6 months post partum. PM2.5 exposure in the first month post partum was associated with a 0.20 SD decline (-0.39 to -0.01; p=0.043) in cortical bone strength until 6 months post partum. Interpretation Ambient PM2.5 exposure during and after pregnancy was associated with diminished trabecular and cortical bone strength. Early pregnancy PM2.5 exposure was associated with a greater decline in bone strength later during pregnancy. Late pregnancy and early post-partum exposures adversely affected the post-partum bone strength recovery. Technological and policy solutions to reduce PM2.5 pollution could improve public health by reducing bone fracture risk.

  • 26.
    Zhao, Yuxuan
    et al.
    Tianjin University, China.
    Wang, Jing
    Tianjin Women and Children's Health Center, China.
    Liu, Gongshu
    Tianjin Women and Children's Health Center, China.
    Ataei, Yeganeh
    Tianjin University, China.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Liu, Wei
    Tianjin University, China.
    Zhang, Qinghao
    Tianjin University, China.
    Huang, Jianjun
    Tianjin University, China.
    Sun, Peizhe
    Tianjin University, China.
    Sun, Yuexia
    Tianjin University, China.
    The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children’s health in Tianjin, China2024In: Hygiene and Environmental Health Advances, ISSN 2773-0492, Vol. 9, article id 100084Article in journal (Refereed)
    Abstract [en]

    The CHemical Exposure and Children’s Health (CHECH) study is an ongoing pregnancy cohort study in Tianjin, China. This paper describes the background, aim and the study design, which can be followed by future researchers to design and conduct similar studies. The abundance and the potential adverse health outcomes of endocrine disrupting chemicals (EDCs) is concerning. More notably, developing fetuses and infants are more vulnerable to EDCs exposure. The CHECH study aims to investigate the importance of early life exposure to multiple EDCs (phthalates and their metabolites, bisphenol A and their substitutes, perfluorinated compounds and poly brominated diphenyl ethers) for multiple health outcomes in Chinese children, namely sexual development, neurodevelopment, metabolism and growth, as well as asthma and allergy. A total of 2238 pregnant women were recruited in Tianjin from May 2017 to April 2021 with a response rate of 90 %. Among these women, 2255 children were born with available information, including 47 pairs of twins. Urine samples were collected from pregnant women and children, while air and dust samples were obtained from the home environment during pregnancy and infancy periods. Information on children’s health was gathered through physical examinations and questionnaires. The CHECH study, which collected exposure information and health outcomes at multiple time points, will contribute to the understanding of prenatal exposure to EDCs and their impact on children’s health, thereby facilitating the development of risk assessments aimed at reducing exposure and associated health risks. 

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  • 27.
    Özel, Faith
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Uppsala University, Sweden.
    Stratmann, Marlene
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Lindh, Christian
    Lund University, Sweden.
    Gennings, Chris
    Icahn School of Medicine at Mount Sinai, United States.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn School of Medicine at Mount Sinai, United States.
    Rüegg, Joëlle
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Uppsala University, Sweden.
    Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study2023In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 178, article id 108029Article in journal (Refereed)
    Abstract [en]

    Background: A growing body of evidence shows that prenatal exposure to phthalates affects child development. Since many phthalates have been shown to alter endocrine signaling, they may influence reproductive development, neurodevelopment, and child behavior. Indeed, a few studies reported associations between prenatal phthalate exposure and gender-specific play behavior. However, evidence for this relationship is limited, and previous findings are based on single phthalates, while human exposure entails mixtures of chemicals. Objective: We aimed to investigate the associations between prenatal exposure to single phthalates, as well as a phthalate mixture, and gender-specific play behavior. Methods: A total of 715 mother–child pairs from the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy (SELMA) study were included. In the median week 10 of pregnancy, phthalate metabolites were measured in urine. Gender-specific play behavior was measured with Preschool Activities Inventory at the age of seven years. Linear and weighted quantile sum regressions were used; data was stratified by sex. Models were adjusted for child and maternal age, maternal education, parental attitudes toward play behavior, and urinary creatinine concentration. Results: For boys, single compound analyses revealed negative associations of prenatal exposure to di-isononyl phthalate (DINP) concentrations with masculine (β = −1.44; 95% CI = −2.72, −0.16) and composite (β = −1.43; 95% CI = −2.72, −0.13) scores. Suggestive associations were also observed with a mixture approach identifying DINP as the main contributor of the association of decreased masculine play. Among girls, higher urinary concentrations of 2,4-methyl-7-oxyooctyl-oxycarbonyl-cyclohexane carboxylic acid (MOiNCH) was associated with decreased feminine (β = −1.59; 95% CI = −2.62, −0.57) and masculine scores (β = −1.22; 95% CI = −2.14, −0.29), whereas the mixture analyses did not yield conclusive results for girls. Conclusion: Our findings suggest associations of prenatal exposure to DINP with decreased masculine play behavior in boys while the results for girls were not fully conclusive.

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