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  • 1.
    Alfredsson, Antonia
    Karlstad University.
    Läkemedelsorsakade förgiftningar i Sveringe: Trender, riskgrupp och tillgång2013Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 2.
    Bjorvang, R. D.
    et al.
    Karolinska institutet.
    Gennings, C.
    Mt Sinai, Dept Environm Med & Publ Hlth, New York.
    Lin, Ping-I
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).
    Hussein, G.
    Centrasjukhuset Karlstad.
    Kiviranta, H.
    Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland.
    Rantakokko, P.
    Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland.
    Ruokojarvi, P.
    Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland.
    Damdimopoulou, P.
    Karolinska institutet.
    Bornehag, Carl-Gustaf
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Mt Sinai, Dept Environm Med & Publ Hlth, New York.
    Persistent organic pollutants, pre-pregnancy use of combined oral contraceptive and time-to-pregnancy in SELMA cohort2018In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, p. S63-S63Article in journal (Refereed)
  • 3.
    Bornehag, Carl-Gustaf
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn Sch Med Mt Sinai, MSSM, New York.
    Gennings, C.
    Icahn Sch Med Mt Sinai, MSSM, New York.
    A novel approach to chemical mixture risk assessment: Linking data from population based epidemiology and experimental animal tests2018In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, p. S52-S52Article in journal (Refereed)
  • 4.
    Dilén, Sofia
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.
    Studier av effekter av epigallokatekin-3-gallat och extrakt av grönt te och kråkbär på prostaglandin E2 bildningen i humana monocyter och makrofager2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 5.
    Fjæraa Alfredsson, Christina
    et al.
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Ding, Menglei
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Liang, Qiu-Li
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Sundström, Birgitta
    Karlstad University, Faculty of Technology and Science.
    Nånberg, Eewa
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells2014In: Biomedicine and Pharmacotherapy, ISSN 0753-3322, E-ISSN 1950-6007, Vol. 68, no 1, p. 129-135Article in journal (Refereed)
    Abstract [en]

    The polyphenol ellagic acid is found in many natural food sources and has been proposed as a candidate compound for clinical applications due to its anti-oxidative capacity and as a potential anti-tumorigenic compound. The objective of the present study was to evaluate the sensitivity to and possible apoptosis mechanism induced by ellagic acid in neuronal tumor cells. As a model the human neuroblastoma SH-SY5Y cell line was used. The methods applied were bright field and phase contrast microscopy, XTT- and LDH-assays, western blot, and flow cytometric analysis of DNA degradation and mitochondrial membrane potential. Ellagic acid treatment was found to induce a reduction in cell number preceded by alterations of the mitochondrial membrane potential and activation of caspase-9 and -3, DNA-fragmentation and cell death by apoptosis. The apoptotic cell death studied was not due to anoikis since it was significant in the adherent fraction of the cells. We conclude that ellagic acid induces dose- and time-dependent apoptosis, at least partly by the mitochondrial pathway, in an embryonal neuronal tumor cell system. This finding is in agreement with previously reported data on adult carcinoma cells thus suggesting a more general effect of ellagic acid on tumor cells.

  • 6.
    Fältsjö, Sara-Stina
    Karlstad University.
    IDP's involvement in the development of antibodies to factor VIII in hemophilia A2013Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 7.
    Hallström, Camilla
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Bacopa monniera och kognitiva effekter hos människa: En granskning av randomiserade, kontrollerade kliniska studier som undersökt kognitiva effekter av Bacopa monniera2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 8.
    Hedgespeth, Melanie
    et al.
    Lund University.
    Nilsson, Per Anders
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Environmental and Life Sciences (from 2013). Lund University.
    Berglund, Olof
    Lund University.
    Assessing potential vulnerability and response of fish to simulated avian predation after exposure to psychotropic pharmaceuticals2016In: Toxics, ISSN 2305-6304, Vol. 4, no 9Article in journal (Refereed)
    Abstract [en]

    Psychotropic pharmaceuticals present in the environment may impact organisms both directly and via interaction strengths with other organisms, including predators; therefore, this study examined the potential effects of pharmaceuticals on behavioral responses of fish to avian predators. Wild-caught juvenile perch (Perca fluviatilis) were assayed using a striking bird model after a seven-day exposure to psychotropic pharmaceuticals (the antidepressants fluoxetine or sertraline, or the -blocker propranolol) under the hypotheses that exposure would increase vulnerability to avian predation via increasing the probability of predator encounter as well as degrading evasive behaviors upon encounter. None of the substances significantly affected swimming activity of the fish, nor did they increase vulnerability by affecting encounter probability or evasive endpoints compared to control treatments. Counter to our expectations, fish exposed to 100 g/L fluoxetine (but no other concentrations or pharmaceuticals) were less likely to enter the open area of the arena, i.e., less likely to engage in risky behavior that could lead to predator encounters. Additionally, all fish exposed to environmentally relevant, low concentrations of sertraline (0.12 g/L) and propranolol (0.1 g/L) sought refuge after the simulated attack. Our unexpected results warrant further research as they have interesting implications on how these psychotropic pharmaceuticals may affect predator-prey interactions spanning the terrestrial-aquatic interface.

  • 9.
    Udéhn, Maria
    Karlstad University.
    Utvecklingen av antiepileptiska läkemedel 1953-2011 samt förskrivningen av ett urval 2006-2012 för barn och ungdommar 0-19 år2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 10.
    van Hees, Anna-Maria
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.
    Receptavvikelser: En studie av typ och frekvens på ett centrumnära svenskt apotek2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 11.
    Zejnullahu, Besart
    Karlstad University.
    Trender av förgiftningar med hänsyn till smärtstillande läkemedel2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
1 - 11 of 11
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