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System peaks and their impact in liquid chromatography
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.
Dept Med Chem, Analyt Pharmaceut Chem, POB 574, SE-75123 Uppsala, Sweden..
2016 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 81, 42-50 p.Article, review/survey (Refereed) Published
Abstract [en]

A sample injected into a chromatographic system can generate extra peaks, called "system peaks", which in general are undetectable. However, for small analytical injections, solute zones eluting with a system zone will often give strongly deformed solute peaks. But, if a solute zone is eluted in a particular region of the system zone it will instead be strongly compressed and well-shaped. For overloaded solute injections, another type of complex band deformation may take place due to large system peaks. This review will present results related to system peak distortions of both small analytical peaks and large preparative ones. Guidelines will be given on how to avoid unwanted distortions and how to utilize the distortions for increased detectability in analytical chromatography, or enhanced production rate in preparative chromatography. The works reviewed here were mainly made by Georges Guiochon, and some of his close colleagues, and is dedicated to his memory. 

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 81, 42-50 p.
Keyword [en]
Liquid chromatography, System peaks, Perturbation peaks, Indirect detection, Peak distortions, Peak compression, Peak deformations, Linear chromatography, Nonlinear chromatography
National Category
Chemical Engineering
Research subject
Chemical Engineering
Identifiers
URN: urn:nbn:se:kau:diva-46237DOI: 10.1016/j.trac.2016.01.008ISI: 000380603600006OAI: oai:DiVA.org:kau-46237DiVA: diva2:972591
Available from: 2016-09-21 Created: 2016-09-21 Last updated: 2016-09-21Bibliographically approved

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Fornstedt, TorgnyForssen, Patrik
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