The management of teams in a distributed IS development project is challenging. It has even been suggested that a new breed of managers for the management of dispersed teams is needed, especially when relationships cross national boundaries. Challenges in distributed, global IS development are understood as related to three dimensions of distance: geographic, temporal, and cultural distance, which affect the manager’s ability to control and coordinate distributed IS development projects. This chapter argues that combining a relationship perspective with a success perspective is fruitful for understanding distributed IS development projects. In this context there are several significant conditions that draw the attention to the challenges in the practice of distributed IS development projects. The chapter ends with the provision of a conceptual framework addressing relational-oriented conditions for the management of distributed IS development projects. Using the framework, managers can identify the relational-oriented conditions for realizing the benefits of distributed IS development projects.