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Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Med Plants Dept, Giza 12622, Egypt..
Natl Res Ctr, Pharmaceut Res Lab, Ctr Excellence Adv Sci, Cairo 12622, Egypt.;Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt..ORCID iD: 0000-0002-6960-027X
Sohag Univ, Dept Zool, Fac Sci, Sohag, Egypt..
Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt..
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2011 (English)In: Natural Product Communications, ISSN 1934-578X, E-ISSN 1555-9475, Vol. 6, no 12, 1809-1812 p.Article in journal (Refereed) PublishedText
Abstract [en]

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.

Place, publisher, year, edition, pages
2011. Vol. 6, no 12, 1809-1812 p.
Keyword [en]
Sarcophyton glaucum, cembrane diterpenes, dihydroxydeepoxysarcophine, sarcophine
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-40599ISI: 000298445300005PubMedID: 22312712OAI: oai:DiVA.org:kau-40599DiVA: diva2:905485
Available from: 2016-02-22 Created: 2016-02-22 Last updated: 2016-02-26Bibliographically approved

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El-Beih, Ahmed A.Abdel-Rehim, MohamedPare, Paul W.
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Department of Chemistry and Biomedical Sciences
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