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Microextraction by packed sorbent (MEPS): A tutorial
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences. AstraZeneca R&D Sodertalje, Global DMPK, SE-15185 Sodertalje, Sweden.;Stockholm Univ, Dept Analyt Chem, SE-10691 Stockholm, Sweden.;Karlstad Univ, Dept Chem & Biomed Sci, Fac Sci & Technol, SE-65188 Karlstad, Sweden..ORCID iD: 0000-0002-3862-8878
2011 (English)In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 701, no 2, 119-128 p.Article in journal (Refereed) PublishedText
Abstract [en]

This tutorial provides an overview on a new technique for sample preparation, microextraction by packed sorbent (MEPS). Not only the automation process by MEPS is the advantage but also the much smaller volumes of the samples, solvents and dead volumes in the system. Other significant advantages such as the speed and the simplicity of the sample preparation process are provided. In this tutorial the main concepts of MEPS will be elucidated. Different practical aspects in MEPS are addressed. The factors affecting MEPS performance will be discussed. The application of MEPS in clinical and pre-clinical studies for quantification of drugs and metabolites in blood, plasma and urine will be provided. A comparison between MEPS and other extraction techniques such as SPE, LLE, SPME and SBSE will be discussed. (C) 2011 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2011. Vol. 701, no 2, 119-128 p.
Keyword [en]
Sample preparation, MEPS, GC-MS, LC-MS, Drug analysis
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-40603DOI: 10.1016/j.aca.2011.05.037ISI: 000294144400001PubMedID: 21801877OAI: oai:DiVA.org:kau-40603DiVA: diva2:905481
Available from: 2016-02-22 Created: 2016-02-22 Last updated: 2016-02-26Bibliographically approved

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Abdel-Rehim, Mohamed
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Department of Chemistry and Biomedical Sciences
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