Change search
ReferencesLink to record
Permanent link

Direct link
A continuum model for hierarchical fibril assembly
Eindhoven University of Technology - P. O. Box 513, NL-5600 MB Eindhoven, The Netherlands.
Eindhoven University of Technology - P. O. Box 513, NL-5600 MB Eindhoven, The Netherlands. (Mathematics)ORCID iD: 0000-0002-1160-0007
Eindhoven University of Technology - P. O. Box 513, NL-5600 MB Eindhoven, The Netherlands.
2014 (English)In: Europhysics letters, ISSN 0295-5075, E-ISSN 1286-4854, Vol. 106, no 6Article in journal (Refereed) PublishedText
Abstract [en]

Most of the biological polymers that make up our cells and tissues are hierarchically structured. For biopolymers ranging from collagen, to actin, to fibrin and amyloid fibrils this hierarchy provides vitally important versatility. The structural hierarchy must be encoded in the self-assembly process, from the earliest stages onward, in order to produce the appropriate substructures. In this letter, we explore the kinetics of multistage self-assembly processes in a model system which allows comparison to bulk probes such as light scattering. We apply our model to recent turbidimetry data on the self-assembly of collagen fibrils. Our analysis suggests a connection between diffusion-limited aggregation kinetics and fibril growth, supported by slow, power-law growth at very long time scales.

Place, publisher, year, edition, pages
Mulhouse, France: Institute of Physics (IOP), 2014. Vol. 106, no 6
Keyword [en]
colagen, coarse graining, homogenisation
National Category
Mathematical Analysis Condensed Matter Physics
Research subject
Mathematics; Physics
Identifiers
URN: urn:nbn:se:kau:diva-39778DOI: 10.1209/0295-5075/106/68004ISI: 000339426500027ScopusID: 2-s2.0-84903641051OAI: oai:DiVA.org:kau-39778DiVA: diva2:901175
Note

cited By 0

Available from: 2016-02-06 Created: 2016-02-06 Last updated: 2016-10-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Muntean, Adrian
In the same journal
Europhysics letters
Mathematical AnalysisCondensed Matter Physics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link