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Solvent strategies for loading and release in mesoporous silica
Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden.
Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences. (INTERACT)ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences. (INTERACT)ORCID iD: 0000-0002-0995-3823
2014 (English)In: Colloid and Interface Science Communications, ISSN 2215-0382, Vol. 3, p. 5-8Article in journal (Refereed) Published
Abstract [en]

A model molecule, ibuprofen, was loaded in the pores of mesoporous silica by adsorption from nonpolar solvents (liquid carbon dioxide and cyclohexane) and from a polar solvent (methanol). It was sufficient with a very low concentration of ibuprofen in the nonpolar solvents to achieve maximum loading of ibuprofen in the mesoporous particles. When using liquid carbon dioxide, the pores of the mesoporous silica particles were filled completely with ibuprofen at a lower ibuprofen concentration than similar experiments performed with cyclohexane. When methanol was used, the maximum amount of loaded ibuprofen was never achieved. Furthermore, x-ray scattering showed that all ibuprofen loaded into the mesoporous particles were in an amorphous state. Ibuprofen was released from the mesoporous particles to water within a couple of minutes, regardless of solvent used for loading. It was found that the release of ibuprofen from mesoporous silica was much faster than that of crystalline ibuprofen.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2014. Vol. 3, p. 5-8
Keyword [en]
Mesoporous silica; Green solvents; Liquid carbon dioxide; Adsorption isotherm
National Category
Physical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-35690DOI: 10.1016/j.colcom.2015.01.001OAI: oai:DiVA.org:kau-35690DiVA, id: diva2:797610
Funder
Knowledge Foundation, 2004/0044
Available from: 2015-03-24 Created: 2015-03-24 Last updated: 2017-12-04Bibliographically approved

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Samuelsson, Jörgenvan Stam, Jan

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