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Methods of Chemical and Physical Modification Used in Increasing Poor Solubility of Orally Administered Medications: -
Karlstad University, Faculty of Health, Science and Technology (starting 2013).
2014 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Poor-water solubility of chemical compounds accounts for 40% and more of new medicalentities become discarded. Low solubility results in chemical substances cannot be deliveredto the target organ or cells, for that reasons there is a need to increase low water-solubilitywith various physical and chemical methods. In this paper we have examined various physicaland chemical methods of increasing poor solubility suggested in the pharmacological booksand journals and looked at how these methods can be practically used in increasing poorwater-solubility of four medications from the WHO Essential List of Medications. Thefindings of the paper are that several methods have shown good results for dissolution invivo: complexation with cyclodextrins and use of surfactants (physical methods), developmentprodrug (chemical methods). Improved medications provide a good solution for chronically illpatients who take high doses over a long period of time. Another benefit of improvedsolubility is lower cost of treatment, which is an important issue in poor regions of the world.

Place, publisher, year, edition, pages
2014. , 30 p.
Keyword [en]
Poor Solubility, Orally Administered, Chemical Methods
National Category
Chemical Process Engineering
URN: urn:nbn:se:kau:diva-32531OAI: diva2:725503
Subject / course
Available from: 2014-06-16 Created: 2014-06-16 Last updated: 2014-06-16Bibliographically approved

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