Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.
1987 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 146, no 2, 456-463 p.Article in journal (Refereed) Published
Prior incubation of quiescent cultures of Swiss 3T3 cells with pertussis toxin selectively inhibited the stimulation of DNA synthesis induced by peptides of the bombesin family. While pertussis toxin blocked mitogenesis at an early stage in the action of the peptide, the toxin did not impair the rapid stimulation of polyphosphoinositide breakdown, Ca2+ mobilization or activation of protein kinase C promoted by bombesin. Thus, inhibition of bombesin-induced mitogenesis by pertussis toxin can be dissociated from inactivation of the phospholipase C signalling pathway.
Place, publisher, year, edition, pages
1987. Vol. 146, no 2, 456-463 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:kau:diva-29821PubMedID: 3039979OAI: oai:DiVA.org:kau-29821DiVA: diva2:657594