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Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.
Department of Metabolic Research, The Wenner-Gren Insitute, University of Stockholm.
1986 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 195, no 1-2, 319-22 p.Article in journal (Refereed) Published
Abstract [en]

alpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.

Place, publisher, year, edition, pages
1986. Vol. 195, no 1-2, 319-22 p.
National Category
Medical and Health Sciences
Research subject
Biomedical Sciences
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URN: urn:nbn:se:kau:diva-29824PubMedID: 3002856OAI: oai:DiVA.org:kau-29824DiVA: diva2:657590
Available from: 2013-10-21 Created: 2013-10-21 Last updated: 2013-10-28Bibliographically approved

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