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Evaluation of a combined linear–nonlinear approach for column characterization using modern alkaline-stable columns as model
Department of Chemistry –BMC, Uppsala University,Uppsala, Sweden.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences. Department of Chemistry –BMC, Uppsala University,Uppsala, Sweden.ORCID iD: 0000-0003-1819-1709
AkzoNobel Pulp & Performance Chemicals AB, Bohus, Sweden.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.
2013 (English)In: Journal of Separation Science, ISSN 1615-9306, E-ISSN 1615-9314, Vol. 36, no 11, 1753-1761 p.Article in journal (Refereed) Published
Abstract [en]

This study investigates if deeper understanding is achieved when combining nonlinear and linear chromatographic column characterization methods. As test systems, two hybrid columns (Phenomenex Gemini-NX C18 and Kromasil Eternity C18) and one classic one (Kromasil-C18) were selected. The nonlinear methods were based on firm adsorption theory and involved determination of adsorption isotherms followed by calculations with a new numerical tool, adsorption energy distribution, on probe components at different pH values. The linear methods involved the hydrophobic subtraction model and selected probe components retention factors as a function of pH. The combined analysis indicated that both complementary and confirmative information can be achieved regarding the actual model systems.

Place, publisher, year, edition, pages
2013. Vol. 36, no 11, 1753-1761 p.
Keyword [en]
Adsorption isotherms, Characterization, Linear methods, Nonlinear methods, Retention
National Category
Analytical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-28105DOI: 10.1002/jssc.201201132ISI: 000319919900009PubMedID: 23554373OAI: oai:DiVA.org:kau-28105DiVA: diva2:631182
Conference
2013/06/10/10:07:39
Available from: 2013-06-20 Created: 2013-06-20 Last updated: 2016-01-26Bibliographically approved

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Samuelsson, JörgenFornstedt, Torgny
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