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Is acetylcholine an autocrine/paracrine growth factor via the nicotinic α-receptor subtype in the human colon cancer cell line HT-29?
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
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2009 (English)In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 609, no 1-3, 27-33 p.Article in journal (Refereed)
Abstract

We used immunochemistry to demonstrate expression of acetylcholine's nicotinic 7-receptor subtype in

human colon cancer cell line HT-29. Moreover, RT-PCR and immunochemistry showed that choline

acetyltransferase and acetylcholine esterase, the enzymes responsible for acetylcholine synthesis and

degradation, respectively, localise in HT-29 cells. Bromoacetylcholine bromide, an inhibitor of choline

acetyltransferase, significantly attenuated basal cell growth. Our findings suggest that acetylcholine might

serve as an autocrine/paracrineor speculatively, even intracrinesignalling molecule in cell line HT-29, thus

contributing to carcinogenesis/cancer progression

Place, publisher, year, edition, pages
2009. Vol. 609, no 1-3, 27-33 p.
Keyword [en]
Acetylcholine, Acetylcholine esterase, Alpha7, Choline acetyltransferase, HT-29, human colon cancer cell line, Nicotinic receptor
National Category
Biological Sciences
Research subject
Biomedical Science
Identifiers
URN: urn:nbn:se:kau:diva-9986OAI: oai:DiVA.org:kau-9986DiVA: diva2:493500
Available from: 2012-02-08 Created: 2012-02-08 Last updated: 2013-06-12Bibliographically approved

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http://dx.doi.org/10.1016/j.ejphar.2009.03.002

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