Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Two-Step method for the Synthesis of a Hydrophilic PDMS Interpenetrating Polymer Network
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
2008 (English)In: Journal of Applied Polymer Science, ISSN 0021-8995, E-ISSN 1097-4628, Vol. 110, no 5, 3059-3067 p.Article in journal (Refereed) Published
Abstract [en]

A hydrophilic PDMS (polydimethylsiloxane) surface was formed by the synthesis of an interpenetrating polymer network (IPN) in a two-step process. In the first step, PDMS was loaded with crosslinker and initiator using a solvent that swells the PDMS. In the second step, the PDMS sample was submerged into a solution containing the hydrophilic monomer followed by a UV-polymerization step. The choice of solvent in the second step is critical to obtain a hydrophilic surface. It can be concluded that the solubility parameter of the solvent should be above a threshold value. Hence, in the second step only sufficiently polar solvents will result in hydrophilic PDMS-IPNs. These principles are illustrated by using N-vinyl-2-pyrrolidone as the hydrophilic monomer forming PVP/PDMS-IPNs.

Place, publisher, year, edition, pages
2008. Vol. 110, no 5, 3059-3067 p.
Keyword [en]
interpenetrating polymer networks (IPN), silicones, hydrogels, thermodynamics, synthesis
National Category
Physical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-4619DOI: 10.1002/app.28485OAI: oai:DiVA.org:kau-4619DiVA: diva2:233515
Available from: 2009-09-01 Created: 2009-09-01 Last updated: 2013-11-06Bibliographically approved
In thesis
1. Effect of solvents during material treatment applications: tuning hydrophilicity of silicone rubber and drug loading in mesoporous silica
Open this publication in new window or tab >>Effect of solvents during material treatment applications: tuning hydrophilicity of silicone rubber and drug loading in mesoporous silica
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Choosing the right solvent is critical for many industrial applications. A useful property for selection of solvents is their solubility parameters. This concept of solubility parameters is central to this thesis and has been used in two different case studies of material treatment applications.

Silicone rubber (crosslinked poly(dimethyl siloxane), PDMS) has many favorable material properties making it useful in biomedical devices. However, a limiting aspect of its material properties is a hydrophobic surface. The aim of this work was to prepare a hydrophilic PDMS material while retaining the transparency of the material. To do this, PDMS was combined with a hydrophilic polymer, polyvinylpyrrolidone (PVP) in an interpenetrating polymer network (IPN). A two-step IPN synthesis method was developed and it was found that the solvent used for polymerization of PVP had a significant influence on the water-wettability and the transparency of the PVP/PDMS IPN. Several different analytical techniques were used for determining the degree of phase separation in the PVP/PDMS IPN. It was found, by using microscopy techniques, that the PVP phase domains varied between 200 nm up to a few micrometers, and the size of the phase domains was correlated to the solvent used for polymerization of the IPN.

The second topic for which solvent effects were explored was for the use of mesoporous silica particles as potential drug delivery devices. In the present work a drug molecule, ibuprofen, was loaded into mesoporous silica particles using different solvents, and in addition adsorption isotherms were established in each solvent. The maximum loading of ibuprofen in the mesoporous material was achieved when using a nonpolar solvent, in particular liquid carbon dioxide was successfully used. One of the advantages of using liquid carbon dioxide is that no solvent residues are left in the final material, which is important for pharmaceutical applications. Furthermore, it was concluded that ibuprofen was stored in an X-ray amorphous form in the mesoporous particles. Release studies in water showed a rapid release of ibuprofen from the mesoporous silica particles, while the dissolution of samples with crystalline ibuprofen was slower. This was verified to be an effect of a larger exposed ibuprofen area in the ibuprofen-loaded mesoporous silica particles, and it was concluded that the intrinsic dissolution rate for the samples were identical.

Place, publisher, year, edition, pages
Karlstad: Karlstad University, 2009. 68 p.
Series
Karlstad University Studies, ISSN 1403-8099 ; 2009:33
Keyword
Solvents, liquid carbon dioxide, Interpenetrating Polymer Network (IPN), silicone rubber, hydrophilic, phase domains, mesoporous silica, ibuprofen, adsorption isotherms, release
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:kau:diva-4118 (URN)978-91-7063-257-0 (ISBN)
Public defence
2009-09-22, Sjöströmssalen. 1B 309, Karlstad universitet, Karlstad, 10:00 (English)
Opponent
Supervisors
Available from: 2009-09-02 Created: 2009-06-01 Last updated: 2011-10-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hillerström, AnnaKronberg, Bengt
By organisation
Department of Chemistry and Biomedical Sciences
In the same journal
Journal of Applied Polymer Science
Physical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 105 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf