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Capillary electrokinetic chromatography for studying interactions between β-blockers and Intralipid emulsion
University of Helsinki, Finland.
University of Helsinki, Finland.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0003-1819-1709
University of Helsinki, Finland.
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2023 (English)In: Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, E-ISSN 1873-264X, Vol. 234, article id 115554Article in journal (Refereed) Published
Abstract [en]

Toxicity of β-blockers is one of the most common causes of poison-induced cardiogenic shock throughout the world. Therefore, methodologies for in vivo removal of the drugs from the body have been under investigation. Intralipid emulsion (ILE) is a common commercial lipid emulsion used for parenteral nutrition, but it has also been administered to patients suffering from drug toxicities. In this work, a set of β-blockers of different hydrophobicity’s (log KD values ranging from 0.16 to 3.8) were investigated. The relative strength of the interactions between these compounds and the ILE was quantitatively assessed by means of binding constants and adsorption constants of the formed β-blocker-ILE complexes. The binding constants were determined by capillary electrokinetic chromatography and the adsorption constants were calculated based on different adsorption isotherms. Expectedly, the binding constants were strongly related to the log KD values of the β-blockers. The binding and adsorption constants also show that less hydrophobic β-blockers interact with ILE, suggesting that this emulsion could be useful for capturing such compounds in cases of their overdoses. Thus, the use of ILE for treatment of toxicities caused by a larger range of β-blockers is worth further investigation. 

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 234, article id 115554
Keywords [en]
Adsorption isotherm, β-blockers, Capillary electrokinetic chromatography, Distribution constant, Drug toxicities, Intralipid emulsion
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-96274DOI: 10.1016/j.jpba.2023.115554ISI: 001033439600001PubMedID: 37399701Scopus ID: 2-s2.0-85163825276OAI: oai:DiVA.org:kau-96274DiVA, id: diva2:1786336
Funder
Knowledge Foundation, 20210021Available from: 2023-08-08 Created: 2023-08-08 Last updated: 2023-08-24Bibliographically approved

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Samuelsson, JörgenFornstedt, Torgny

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