Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • apa.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Systematic review reveals sexually antagonistic knockouts in model organisms
University of Sussex, United Kingdom.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Environmental and Life Sciences (from 2013).ORCID iD: 0000-0002-1853-7469
2022 (English)In: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 12, no 12, article id e9671Article, review/survey (Refereed) Published
Abstract [en]

Sexual antagonism is thought to be an important selective force in multiple evolutionary processes, but very few examples of the genes involved are known. Such a deficit of loci could partially be explained by the lack of overlap in terminology between scientific disciplines. Following a similar review in humans, we searched systematically for studies that described genes with sexually antagonistic or sex-opposite effects in any taxa, using terms designed to capture alternative descriptions of sexual antagonism. Despite drawing on a potentially very large pool of studies we found only eight articles, which between them described seven candidate variants, five of these were gene knockouts. In every case, the variants had net negative effects on the focal trait. One locus was independently validated between studies, but in comparison to previous data on variants in humans and the fruit-fly, the studies generally suffered from small sample sizes, with concomitant high variance. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss. We searched systematically for genetic variants with sexually antagonistic or sex-opposite effects in any taxa. Of 2116 articles, we found seven candidate variants, five of which were gene knockouts. Our review highlights the radically different effects that gene deletions can have on males and females, where the beneficial effects seen in one sex may facilitate the evolution of gene loss.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 12, no 12, article id e9671
Keywords [en]
evolutionary genomics, fitness, selection-sexual, sexual conflict
National Category
Evolutionary Biology
Research subject
Biology
Identifiers
URN: urn:nbn:se:kau:diva-93024DOI: 10.1002/ece3.9671ISI: 000905463200001PubMedID: 36619711Scopus ID: 2-s2.0-85145311068OAI: oai:DiVA.org:kau-93024DiVA, id: diva2:1729783
Funder
Swedish Research Council, 2019‐03567Available from: 2023-01-23 Created: 2023-01-23 Last updated: 2023-05-02Bibliographically approved

Open Access in DiVA

fulltext(603 kB)69 downloads
File information
File name FULLTEXT01.pdfFile size 603 kBChecksum SHA-512
1393740f07051f1dad5e13bcc2e70a508ca58ff7b74791699773871bd4a27611bcd220c9c9eed73a98b59480b942060e5fc47508b406dd976c0fe51bb982e30c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Morrow, Edward H.

Search in DiVA

By author/editor
Morrow, Edward H.
By organisation
Department of Environmental and Life Sciences (from 2013)
In the same journal
Ecology and Evolution
Evolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 69 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 119 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • apa.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf