Situated within feminist technoscience studies and affect theory, this article explores themethodological specificities of working with Drosophila Melanogaster, commonly known as fruitflies. Based on a year of participatory observation in a fly lab, the article challenges the moder-nist imaginaries of laboratory work as disembodied, detached and objective. It suggests that la-boratory work is instead an interactive, embodied and affective process that takes place in prox-imity between human and non-human, subject and object. The article therefore contributes toearlier feminist science studies arguing that doing science is an interactive, procedural, socio-cul-tural phenomenon. However, while most such previous works focus on issues such as connec-tions, companionship, love and empathy, this article asks what methodological contributions cancome from experiencing the intensity of more than human encounters that inspire undesirablefeelings such as disgust.