Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Peak Distortions in Preparative Supercritical Fluid Chromatography: A More Complete Overview
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0002-7123-2066
2016 (English)In: Chromatography Today, ISSN 0143-5140, Vol. 9, no 3, p. 10-14Article in journal (Other academic) Published
Abstract [en]

Supercritical Fluid Chromatography (SFC) has re-emerged as a first-rate technique for purification of candidate drugs in the pharmaceuticalindustry; fuelled by new and improved instrumentation and a rapidly growing interest in the scientific community. SFC is considered much morecomplex and difficult than HPLC by new users but that is largely compensated for by strong advantages such as lower environmental impact andthe much shorter separation times and thus larger production rates. However, there are remaining challenges and difficulties with packed columnSFC, the most studied are those resulting from the compressibility of the mobile phase, leading to the concept that SFC is a ‘rubber variant’of HPLC, where everything considered constant in HPLC, is not in SFC. In this article we will discuss and review, with new and review materialsanother challenge not often addressed in SFC - the fact that sample components cannot be dissolved in the mobile phase, but have to bedissolved in a solvent, and what type of peak distortions that may generate.

Place, publisher, year, edition, pages
2016. Vol. 9, no 3, p. 10-14
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-71671OAI: oai:DiVA.org:kau-71671DiVA, id: diva2:1300793
Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-03-29Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Fornstedt, Torgny

Search in DiVA

By author/editor
Fornstedt, Torgny
By organisation
Department of Engineering and Chemical Sciences (from 2013)
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf