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Prenatal phthalate exposure was associated with croup in Swedish infants
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013).ORCID iD: 0000-0002-3395-2409
School of Medical Sciences, Örebro University, Örebro, Sweden.
Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 6, p. 1011-1019Article in journal (Refereed) Published
Abstract [en]

Aim: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. Methods: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders. Results: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life. Conclusion: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 107, no 6, p. 1011-1019
National Category
Pediatrics Public Health, Global Health and Social Medicine Respiratory Medicine and Allergy
Research subject
Public Health Science; Biomedical Sciences
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URN: urn:nbn:se:kau:diva-67368DOI: 10.1111/apa.14245ISI: 000431956700017PubMedID: 29385277OAI: oai:DiVA.org:kau-67368DiVA, id: diva2:1209823
Available from: 2018-05-24 Created: 2018-05-24 Last updated: 2025-02-21Bibliographically approved

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Shu, HuanNånberg, EewaBornehag, Carl-Gustaf

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