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Schrödinger's capsule : a (micro) capsulate that is open and closed, almost, at the same time
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Physics. (Material Physics)ORCID iD: 0000-0001-9337-2249
2010 (English)In: Proceedings of the Physics with Industry 2010, 11-15 October 2010, Leiden, The Netherlands / [ed] Lorentz Center Leiden, Lorentz Center Leiden , 2010Conference paper, Published paper (Refereed)
Abstract [en]

We exploit different routes for encapsulation of food additives, such as minerals or

vitamins, in a polymeric capsule. The added active ingredients should remain inside the

capsule for at least a year in an aqueous environment (e.g. a dairy product), since

sensory properties or functionality of the ingredients may otherwise be affected.

However, after intake the active compound should readily (within 1 h) be released due

to the acidic environment in the stomach. First, we propose a phenomenological model

in order to study how a polymeric matrix may limit the diffusion of incorporated active

molecules. The relation between the release rate of the active compound and its

molecular weight is elucidated. Second, the desired capsules may be obtained by specific

binding between subunits within the capsule and the active ingredient. We show two

examples that rely on this mechanism: amylose-lipid complexes and mixed metal

hydroxides. Amylose is able to form inclusion complexes with various types of ligands,

including iodine, monoglycerides, fatty acids and alcohols, where the hydrophobic parts

of the ligands are entrapped in the hydrophobic helical cavity of amylose. Mixed metal

hydroxides are a versatile class of inorganic solids that consist of sheets of metal cations

that are octahedrally surrounded by hydroxide molecules. In between these layers

anionic species compensate for charge neutrality. In this way, various metal cations

(minerals) may be incorporated with a high loading, and negatively charged actives may

be placed between the layers. Upon digestion the particles dissolve and the ingredients

are digested. Finally, we show that nature has already developed many intriguing

capsules.

Place, publisher, year, edition, pages
Lorentz Center Leiden , 2010.
National Category
Natural Sciences Other Physics Topics
Identifiers
URN: urn:nbn:se:kau:diva-66749OAI: oai:DiVA.org:kau-66749DiVA, id: diva2:1191634
Conference
Physics with Industry 2010, 11-15 October 2010, Leiden, The Netherlands
Available from: 2018-03-19 Created: 2018-03-19 Last updated: 2018-03-19

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https://pure.tue.nl/ws/files/3019532/Metis246570.pdf

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CiteExportLink to record
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