An innovative creping simulator for tissue has been developed to meet the requirements set by both industrial needs, such as speed and process step duration, and research ambitions, such as flexibility for modifications and efficient operation. Some of these factors can be difficult to achieve with the previously introduced simulators. Lower speeds and much longer process step times can jeopardize results when, for instance, the drying time of chemicals is longer and the speed of creping is slower than in a tissue mill. The newly developed simulator has been used to investigate the effects of paper grammage, creping angle, temperature of dryer, speed and the horizontal force experienced during tissue creping. Results show good agreement with results of industrial-scale tissue production, with the exception of shrinkage which was greater. It was observed that the grammage influences the final thickness and the shrinkage of creped sheets, and that creping speed affects the creping frequency, thickness and shrinkage. The temperature of the surface of a sled mimicking the Yankee cylinder was shown to influence creping frequency and thickness. The horizontal friction force during creping appears to increase if drying temperature is lowered.