Mobile internet usage has significantly raised over the last decade and it is expected to grow to almost 4 billion users by 2020. Even after the great effort dedicated to the improvement of the performance, there still exist unresolved questions and problems regarding the interaction between TCP and mobile broadband technologies such as LTE. This chapter collects the behavior of distinct TCP implementation under various network conditions in different LTE deployments including to which extent the performance of TCP is capable of adapting to the rapid variability of mobile networks under different network loads, with distinct flow types, during start-up phase and in mobile scenarios at different speeds. Loss-based algorithms tend to completely fill the queue, creating huge standing queues and inducing packet losses both under stillness and mobility circumstances. On the other side delay-based variants are capable of limiting the standing queue size and decreasing the amount of packets that are dropped in the eNodeB, but they are not able under some circumstances to reach the maximum capacity. Similarly, under mobility in which the radio conditions are more challenging for TCP, the loss-based TCP implementations offer better throughput and are able to better utilize available resources than the delay-based variants do. Finally, CUBIC under highly variable circumstances usually enters congestion avoidance phase prematurely, provoking a slower and longer start-up phase due to the use of Hybrid Slow-Start mechanism. Therefore, CUBIC is unable to efficiently utilize radio resources during shorter transmission sessions.