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PVC flooring at home and uptake of phthalates in pregnant women
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences.ORCID iD: 0000-0002-3395-2409
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(English)Manuscript (preprint) (Other academic)
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:kau:diva-62630OAI: oai:DiVA.org:kau-62630DiVA: diva2:1130756
Available from: 2017-08-11 Created: 2017-08-11 Last updated: 2017-08-13
In thesis
1. Phthalates: On the issue of sources, human uptake, time trends and health effects
Open this publication in new window or tab >>Phthalates: On the issue of sources, human uptake, time trends and health effects
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals. EDCs are manmade compounds (there are also natural compounds with such properties) that can bind to cell receptors and mimic or block the functions of natural hormones potentially resulting in adverse human health effects.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates. According to the World Health Organization, EDCs are suspected to be associated with altered reproductive function in males and females, increased incidence of breast cancer, abnormal growth patterns and neurodevelopmental delays in children, as well as changes in immune function.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children.

As we have shown, ongoing regulations on phthalates is of importance for human uptake. Ultimately, individuals can make small changes in their consumer product choices that can lead to changes in uptake of chemicals with endocrine disrupting properties. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates resulting in implementation of regulations.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children. This means that regulation and consumers’ product choices can lead to changes in uptake of EDCs of importance for human health. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

Place, publisher, year, edition, pages
Karlstads universitet, 2017. 61 p.
Series
Karlstad University Studies, ISSN 1403-8099 ; 2017:30
Keyword
Phthalates, Asthma, Pregnant, Exposure, Endocrine disrupting chemicals, SELMA
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
urn:nbn:se:kau:diva-62637 (URN)978-91-7063-806-0 (ISBN)978-91-7063-902-9 (ISBN)
Public defence
2017-09-29, 1B306 (Fryxellsalen), Universitetsgatan 2, Karlstad, 13:00 (English)
Opponent
Supervisors
Available from: 2017-09-08 Created: 2017-08-13 Last updated: 2017-09-08Bibliographically approved

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