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Volatile organic compounds of possible microbial origin and their risks on childhood asthma and allergies within damp homes
SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Albany, NY 12222 USA.
Norwegian Inst Air Res, POB 100, N-2027 Kjeller, Norway.;Norwegian Inst Air Res, Inst Tveien 18, N-2007 Kjeller, Norway.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences. Tech Res Inst Sweden, Box 857, SE-50115 Boras, Sweden.
2017 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 98, 143-151 p.Article in journal (Refereed) Published
Abstract [en]

Background: Risk of indoor exposure to volatile organic compounds of purported microbial origin on childhood symptoms of wheezing, rhinitis, and/or eczema, and doctor-diagnosed asthma, rhinitis, and eczema, respectively, remain unclear. Objective: To test hypotheses that total sum of 28 microbial volatile organic compounds (Sigma 26 MVOCs): 1) poses independent risk on doctor-diagnosed asthma, rhinitis, and eczema, respectively, as well as multiple symptom presentation with a minimum of the two of the above conditions (i.e. case); 2) is associated with significant interaction with absolute humidity (AH) on additive scale. Methods: In a case-control investigation, 198 cases and 202 controls were examined during November 2001 March 2002 period through homeindoor air sampling, air quality inspection, and health outcome ascertainment. Results: Not only the Sigma 28 MVOCs but also the global MVOC index were significantly higher within the homes of the cases with a high AH, compared to the controls with a low AH (all Ps < 0.001). Only the cases, but not the controls, were associated with a dose-dependent increase in the exposure variables of interest (Sigma 28 MVOCs) per quartile increase in AH (P < 0.0001 for the cases; P = 0.780 for the controls). Only among the children who live in a high AH homes, a natural log (ln)-unit of Sigma 28 MVOCs was associated with 2.5-times greater odds of the case status (95% CI, 1.0-6.2; P = 0.046), compared to 0.7-times the odds (95% CI, 0.4-1.0; P = 0.074) of the same outcome among the low AH homes. Specifically, joint exposure to a high MVOCs and high AH was associated with 2.6-times greater odds of the doctor-diagnosed asthma status (95% CI, 0.7-8.91; P = 0.137). Conclusion: Joint occurrence of high Sigma 28 MVOCs and AH was associatedwith a significant increase in the case status and asthma risks in an additive scale.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 98, 143-151 p.
Keyword [en]
Indoor, Allergy, Damp, Mold, VOC, Childhood
National Category
Health Sciences
Research subject
Public Health Science
Identifiers
URN: urn:nbn:se:kau:diva-62593DOI: 10.1016/j.envint.2016.10.028ISI: 000389913500017PubMedID: 27838117OAI: oai:DiVA.org:kau-62593DiVA: diva2:1130301
Available from: 2017-08-09 Created: 2017-08-09 Last updated: 2017-08-09Bibliographically approved

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