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Syntes av cyklo (leu-phe-gly-glu(O(CH2)9CO2H)-trp-pro) Kiral Stationärfas HPLC
2000 (Swedish)Independent thesis Basic level (professional degree)Student thesis
Abstract [sv]

In some fields of science it is of most importance to work with enantiomericaly pure substances as fore example in the drug industry since it has been shown that different isomers might have different biological activity. One example is the drug neurosedyn that was given to pregnant women in the 60ths. Later on it was discovered that one of the isomer gave damage to the fetus. The way of making enantiomericaly pure substances is called asymmetric synthesis. This is often expensive and a lot of hard work need to be done, therefore it is of most interest to find a good way to separate chiral compounds. _x000B_In this work a cyclic hexapeptide have been synthesized. The ability of the peptide to separate different chiral compounds have been investigated with 1D titration in H-NMR. The NMR experiment showed that the peptide could differ between L- and D-serine. A first screening experiment with the peptide as a chiral stationary phases has also been performed. Elution of different chiral aminoacids showed that there was a difference in retentiontime between N-tBoc L and D- tryptophan but further experiments has to be done.

Place, publisher, year, edition, pages
2000. , 25 p.
Identifiers
URN: urn:nbn:se:kau:diva-52416Local ID: KEM-10OAI: oai:DiVA.org:kau-52416DiVA: diva2:1100942
Subject / course
Chemistry
Available from: 2017-05-29 Created: 2017-05-29

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