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Sample introduction for high performance separations
Univ Western Sydney, Sch Sci & Hlth, Australian Ctr Res Separat Sci ACROSS, North Parramatta, NSW 2150, Australia.;Karlstad Univ, INTERACT, Dept Engn & Chem Sci, SE-65188 Karlstad, Sweden..
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0002-7123-2066
2016 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 81, p. 34-41Article, review/survey (Refereed) Published
Abstract [en]

In this review we discuss how viscosity contrasts between the injection plug and the mobile phase may lead to loss in separation performance, especially in UHPLC columns or SFC environments. Firstly, the wall effect is discussed, and how it can amplify viscosity contrast effects. We then illustrate how viscosity contrasts lead to the phenomenon known as viscous fingering, and we detail the destructive effects of this phenomenon. We expand on the viscous fingering component, however, demonstrating that viscosity contrast effects begin to deteriorate performance long before the conditions are such that viscous fingering occurs. Subtle changes in band-shape are apparent even with very low viscosity contrasts. Lastly we illustrate how viscosity contrast effects lead to severe peak distortions in SFC. Analysts who seek high efficiency separations must make every effort to eliminate, or at least minimise the viscosity contrast between the injection plug and the mobile phase. 

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 81, p. 34-41
Keywords [en]
The wall effect, Viscous fingering, UHPLC, Supercritical fluid chromatography, Mixed stream injection, HPLC, Viscosity contrasts
National Category
Chemical Engineering
Research subject
Chemical Engineering
Identifiers
URN: urn:nbn:se:kau:diva-46238DOI: 10.1016/j.trac.2016.01.004ISI: 000380603600005OAI: oai:DiVA.org:kau-46238DiVA, id: diva2:972592
Available from: 2016-09-21 Created: 2016-09-21 Last updated: 2019-07-12Bibliographically approved

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Samuelsson, Jörgen

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