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Sample treatment based on extraction techniques in biological matrices
Najd Consulting Hosp, Riyadh, Saudi Arabia..
Karlstads universitet, Fakulteten för teknik- och naturvetenskap, Avdelningen för kemi och biomedicinsk vetenskap. AstraZeneca R&D Sodertalje, Clin Pharmacol, SE-15185 Sodertalje, Sweden.;AstraZeneca R&D Sodertalje, DMPK, SE-15185 Sodertalje, Sweden.;Karlstad Univ, Dept Chem & Biomed Sci, SE-65188 Karlstad, Sweden.;Stockholm Univ, Dept Analyt Chem, SE-10691 Stockholm, Sweden..ORCID-id: 0000-0002-3862-8878
2011 (engelsk)Inngår i: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 3, nr 17, s. 2003-2018Artikkel, forskningsoversikt (Fagfellevurdert) Published
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Abstract [en]

The importance of sample preparation methods as the first stage in bioanalysis is described. In this article, the sample preparation concept and strategies will be discussed, along with the requirements for good sample preparation. The most widely used sample preparation methods in the pharmaceutical industry are presented; for example, the need for same-day rotation of results from large numbers of biological samples in pharmaceutical industry makes high throughput bioanalysis more essential. In this article, high-throughput sample preparation techniques are presented; examples are given of the extraction and concentration of analytes from biological matrices, including protein precipitation, solid-phase extraction, liquid-liquid extraction and microextraction-related techniques. Finally, the potential role of selective extraction methods, including molecular imprinted phases, is considered.

sted, utgiver, år, opplag, sider
2011. Vol. 3, nr 17, s. 2003-2018
HSV kategori
Forskningsprogram
Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:kau:diva-40607DOI: 10.4155/BIO.11.201ISI: 000295210300017PubMedID: 21899508OAI: oai:DiVA.org:kau-40607DiVA, id: diva2:905478
Tilgjengelig fra: 2016-02-22 Laget: 2016-02-22 Sist oppdatert: 2017-11-30bibliografisk kontrollert

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