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Intravital fluorescent microscopic evaluation of bacterial cellulose as scaffold for vascular grafts
Sahlgrens Univ Hosp, Vasc Engn Ctr, Gothenburg, Sweden..
Sahlgrens Univ Hosp, Vasc Engn Ctr, Gothenburg, Sweden..
Univ Saarland, Inst Clin & Expt Surg, D-6650 Homburg, Saarland, Germany..
Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden..
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2010 (Engelska)Ingår i: Journal of Biomedical Materials Research. Part A, ISSN 1549-3296, E-ISSN 1552-4965, Vol. 93A, nr 1, s. 140-149Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Although commonly used synthetic vascular grafts perform satisfactorily in large caliber blood vessels, they are prone to thrombosis in small diameter vessels. Therefore, small vessels might benefit from tissue engineered vascular grafts. This study evaluated bacterial cellulose (BC) as a potential biomaterial for biosynthetic blood vessels. We implanted the dorsal skinfold chambers in three groups of Syrian golden hamsters with BC (experimental group), polyglycolic acid, or expanded polytetrafluorethylane (control groups). Following implantation, we used intravital fluorescence microscopy, histology, and immunochemistry to analyze the biocompatibility, neovascularization, and incorporation of each material over a time period of 2 weeks. Biocompatibility was good in all groups, as indicated by the absence of leukocyte acti-vation upon implantation. All groups displayed angiogenic response in the host tissue, but that response was highest in the polyglycolic acid group. Histology revealed vascularized granulation tissue Surrounding all three biomaterials, with many proliferating cells and a lack of apoptotic cell death 2 weeks after implantation. In conclusion, BC offers good biocompatibility and material incorporation compared with commonly used materials in vascular surgery. Thus, BC represents a promising new biomaterial for tissue engineering of vascular grafts. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 140-149, 2010

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2010. Vol. 93A, nr 1, s. 140-149
Nyckelord [en]
bacterial cellulose, biomaterial, biocamptability, dorsal skinfold chamber, intravital fluorescence microscopy
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
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Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:kau:diva-40510DOI: 10.1002/jbm.a.32516ISI: 000275131800016PubMedID: 19536832OAI: oai:DiVA.org:kau-40510DiVA, id: diva2:905336
Tillgänglig från: 2016-02-22 Skapad: 2016-02-17 Senast uppdaterad: 2017-11-30Bibliografiskt granskad

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Delbro, Dick

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Journal of Biomedical Materials Research. Part A
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

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