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Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.
Department of Metabolic Research, The Wenner-Gren Insitute, University of Stockholm.
1986 (engelsk)Inngår i: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 195, nr 1-2, s. 319-22Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

alpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.

sted, utgiver, år, opplag, sider
1986. Vol. 195, nr 1-2, s. 319-22
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Biomedicinsk vetenskap
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URN: urn:nbn:se:kau:diva-29824PubMedID: 3002856OAI: oai:DiVA.org:kau-29824DiVA, id: diva2:657590
Tilgjengelig fra: 2013-10-21 Laget: 2013-10-21 Sist oppdatert: 2017-12-06bibliografisk kontrollert

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