Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Modeling of Preparative Liquid Chromatography
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.ORCID iD: 0000-0002-7123-2066
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.ORCID iD: 0000-0003-1819-1709
2013 (English)In: Liquid Chromatography: Fundamentals and Instrumentation / [ed] Salvatore Fanali, Paul R. Haddad; Poole, Colin; Schoenmakers, Peter; Lloyd, David K., Elsevier, 2013, p. 407-425Chapter in book (Refereed)
Abstract [en]

Abstract Preparative chromatography is today the best generic method for the purification of small drugs and valuable chemical components at the <10 kg-level. Recent progress in computer technology and the development of new nonchiral and chiral stationary phases, as well as numerous improvements in reliability and economic performance, have considerably increased the interest in modeling in academic and industrial communities. This chapter serves as an introduction to the field of modeling preparative liquid chromatography in the classical batch mode, aiming at improved process purification of valuable chemical components, drugs, and chiral components. We go through the most important column and adsorption models and methods for determination of the essential thermodynamic adsorption data for both column characterization and process improvement. But, we also cover important operational conditions sometimes neglected in the modeling procedure, such as the impact of injection profiles and accounting for the additive in the modeling procedure.

Place, publisher, year, edition, pages
Elsevier, 2013. p. 407-425
National Category
Chemical Engineering
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-29331DOI: 10.1016/B978-0-12-415807-8.00018-3ISI: 000323422900018ISBN: 978-0-12-415807-8 (print)OAI: oai:DiVA.org:kau-29331DiVA, id: diva2:654741
Note

Chapter 18

Available from: 2013-10-08 Created: 2013-10-08 Last updated: 2018-03-29Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full texthttp://www.sciencedirect.com/science/article/pii/B9780124158078000183

Authority records BETA

Fornstedt, TorgnyForssén, PatrikSamuelsson, Jörgen

Search in DiVA

By author/editor
Fornstedt, TorgnyForssén, PatrikSamuelsson, Jörgen
By organisation
Department of Engineering and Chemical Sciences
Chemical Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetric score

doi
isbn
urn-nbn
Total: 120 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf