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Using Modern SFC Systems for Adsorption Characterization
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences.ORCID iD: 0000-0002-8943-6286
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-7123-2066
2013 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

Recently the pharmaceutical industry has started to replace preparative HPLC with preparative SFC to lower the environmental impact and to increase performance. Reliable characterization of the adsorption processes in SFC is therefore of utmost importance. The key thermodynamic phase system information is obtained by rigorous determination of adsorption isotherm data over a broad concentration range. If properly processed, this data gives not only correct information about the degree of heterogeneity but also the energy of interactions and mono layer capacities of each individual type of adsorption site in the phase system. Ultimately, this can result in identification of the types of interactions, i.e., dipole-dipole, van der Waals interactions etc. In this study we will present transfer of selected adsorption characterization methods, traditionally applied with success in LC, to SFC. We have here transferred all available knowledge from LC – from model selection to validation. We will also, using recent findings, explain the effects of pressure and temperature variations as well as how to accurately measure the volumetric flow rate on a modern analytical SFC system. We will demonstrate how the latest SFC instruments, with some critical modifications; have the potential for rapid and reliable acquisition of thermodynamic data using the ECP method. Finally we will elaborate on how the adsorption depends on density, temperature and modifier content in the mobile phase. This is a contribution from the Fundamental Separation Science Group www.FSSG.se

Place, publisher, year, edition, pages
Boston, MA, USA, 2013.
National Category
Analytical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-28812OAI: oai:DiVA.org:kau-28812DiVA, id: diva2:644071
Conference
26th International Symposium, Exhibit & Workshops on Preparative & Process Chromatography, Boston, USA, July 14-17, 2013.
Available from: 2013-08-29 Created: 2013-08-29 Last updated: 2019-07-12Bibliographically approved

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Enmark, MartinSamuelsson, JörgenFornstedt, Torgny

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