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Highlighting Important Parameters Often Neglected in Numerical Optimization of Preparative Chromatography
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-8943-6286
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-7123-2066
2012 (English)In: Chemical Engineering & Technology, ISSN 0930-7516, E-ISSN 1521-4125, Vol. 35, no 1, p. 149-156Article in journal (Refereed) Published
Abstract [en]

When a chromatographic separation process is numerically optimized, a number of input parameters to the column model need to be accurately determined, and the accuracy will affect the reliability of the predicted optimal operational conditions. Furthermore, the numerical accuracy of the solution to the column model will have similar impact. The input parameters holdup volume, injection profiles, and the selection of an algorithm for solving the column model were investigated. Errors in parameters or a numerical error in the solution of the column model were found to lead to a prediction of a product fraction where the set purity and/or yield requirements are not met.

Place, publisher, year, edition, pages
2012. Vol. 35, no 1, p. 149-156
Keywords [en]
Equilibrium dispersive model, Holdup volume, Injection profile, Langmuir model, Numerical solution, Preparative chromatography
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-15247DOI: 10.1002/ceat.201100210ISI: 000298540200013OAI: oai:DiVA.org:kau-15247DiVA, id: diva2:562026
Available from: 2012-10-23 Created: 2012-10-23 Last updated: 2019-07-12Bibliographically approved

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Publisher's full texthttp://onlinelibrary.wiley.com/doi/10.1002/ceat.201100210/abstract

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Samuelsson, JörgenEnmark, MartinForssén, PatrikFornstedt, Torgny

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