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Enantioseparation of omeprazole effect of different packing particle size on productivity
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-8943-6286
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
Karlstad University, Faculty of Technology and Science, Department of Chemistry and Biomedical Sciences.
2012 (English)In: Journal of Chromatography A, ISSN 0021-9673, Vol. 1240, no 1, p. 123-131Article in journal (Refereed) Published
Abstract [en]

Enantiomeric separation of omeprazole has been extensively studied regarding both product analysis and preparation using several different chiral stationary phases. In this study, the preparative chiral separation of omeprazole is optimized for productivity using three different columns packed with amylose tris (3,5-dimethyl phenyl carbamate) coated macroporous silica (5, 10 and 25 Όm) with a maximum allowed pressure drop ranging from 50 to 400 bar. This pressure range both covers low pressure process systems (50–100 bar) and investigates the potential for allowing higher pressure limits in preparative applications in a future. The process optimization clearly show that the larger 25 Όm packing material show higher productivity at low pressure drops whereas with increasing pressure drops the smaller packing materials have substantially higher productivity. Interestingly, at all pressure drops, the smaller packing material result in lower solvent consumption (L solvent/kg product); the higher the accepted pressure drop, the larger the gain in reduced solvent consumption. The experimental adsorption isotherms were not identical for the different packing material sizes; therefore all calculations were recalculated and reevaluated assuming identical adsorption isotherms (with the 10 Όm isotherm as reference) which confirmed the trends regarding productivity and solvent consumption.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2012. Vol. 1240, no 1, p. 123-131
Keywords [en]
Column geometry, Inverse method, Omeprazole, Optimization, Preparative chromatography, Productivity
National Category
Analytical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-15248DOI: 10.1016/j.chroma.2012.03.085ISI: 000304491700014OAI: oai:DiVA.org:kau-15248DiVA, id: diva2:562022
Available from: 2012-10-23 Created: 2012-10-23 Last updated: 2017-12-06Bibliographically approved

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Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S0021967312005304http://www.journals.elsevier.com/journal-of-chromatography-a

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Enmark, MartinSamuelsson, JörgenForssén, PatrikFornstedt, Torgny

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