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Evaluating the advantages of higher heat conductivity in a recently developed type of core-shell diamond stationary phase particle in UHPLC
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013). Rzeszów University of Technology, POL.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0003-1819-1709
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).ORCID iD: 0000-0001-8561-6872
Rzeszów University of Technology, POL.
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2020 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1625, article id 461076Article in journal (Refereed) Published
Abstract [en]

In recent studies, the nature and magnitude of the temperature gradients developed in ultra-high pressure liquid chromatography (UHPLC), were found to be dependent on the heat conductivity properties of the column matrices, but also, on the principle used for controlling the temperature over the column. Here, we investigated the potential of using highly heat conductive diamond-based stationary phases (85 times higher than silica), for reducing the temperature gradients. The stationary phases investigated were a (i) Diamond Analytics FLARE column, based on particles comprised of a graphite core surrounded by a very thin diamond shell, and two silica hybrid columns: (ii) a core-shell silica Kromasil Eternity Shell column and (iii) a fully porous silica Kromasil Eternity XT column. Models were developed based on two-dimensional heat transfer theory and mass transfer theory, which were used to model the temperature profiles and the migration of an analyte band accounting for column efficiencies at different flow rates. For the silica-based columns, using water-controlled temperature mode, the temperature gradients along the column axes are suppressed whereas temperature gradients in the radial direction prevails resulting in decreased column efficiencies. Using these columns with air-controlled temperature mode, the radial temperature gradients are reduced whereas temperature gradients along the column prevails resulting in decreased retention times. With the Diamond FLARE column, there was no loss in column efficiency using the water-controlled temperature mode and the van Deemter curves are almost identical using both temperature control modes. Thus, for the Diamond FLARE column, in contrast to the silica-based columns, there are almost no losses of column efficiencies due to reduced radial temperature gradients independent on how the column temperature was controlled.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 1625, article id 461076
Keywords [en]
Column efficiency, Core-shell particles, Diamond FLARE column, Temperature control, Temperature gradient, Viscous heating, Diamonds, Efficiency, Heat conduction, High pressure liquid chromatography, Mass transfer, Shells (structures), Silica, Thermal conductivity, Thermal gradients, Column temperature, Conductive diamonds, Controlled temperature, Mass transfer theories, Radial temperature gradients, Temperature profiles, Two-dimensional heat transfer, Ultra high pressure liquid chromatography (UHPLC), Column chromatography
National Category
Chemical Sciences Analytical Chemistry
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:kau:diva-78200DOI: 10.1016/j.chroma.2020.461076ISI: 000552017600001Scopus ID: 2-s2.0-85083067269OAI: oai:DiVA.org:kau-78200DiVA, id: diva2:1439725
Funder
Swedish Research Council, 2015-04627Available from: 2020-06-12 Created: 2020-06-12 Last updated: 2021-04-01Bibliographically approved

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Lesko, MarekSamuelsson, JörgenÅsberg, DennisFornstedt, Torgny

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