Combinatorial interaction testing (CIT) is a well-known technique,but the industrial experience is needed to determine its effectivenessin different application domains. We present a case study introducinga unified framework for generating, executing and verifyingCIT test suites, based on the open-source Avocado test framework.In addition, we present a new industrial case study to demonstratethe effectiveness of the framework. This evaluation showed thatthe new framework can generate, execute, and verify effective combinatorialinteraction test suites for detecting configuration failures(invalid configurations) in a virtualization system.