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Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Stockholms universitet.ORCID iD: 0000-0002-3395-2409
Lunds universitet.ORCID iD: 0000-0001-7435-9890
Örebro univeristet.
Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Health Sciences (from 2013). Icahn Sch Med Mt Sinai, Dept Prevent Med, New York.ORCID iD: 0000-0003-0417-1686
2018 (English)In: PLoS ONE, E-ISSN 1932-6203, Vol. 13, no 12, article id e0209255Article in journal (Refereed) Published
Abstract [en]

Background Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development. Methods Perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) were analyzed by LC/MS/MS in serum from 1,616 pregnant women in the Swedish SELMA study. The serum samples were collected in the first trimester (median week 10). Least square geometric means (LSGM) of PFAS were estimated for each year period for, adjusted for potential determinants including parity, fish intake in the family, and mother's age. Results Six PFAS (PFNA, PFDA, PFUnDA, PFHxS, PFOA, and PFOS) were detected above levels of detection (LOD) in more than 99% of the SELMA women, while PFHpA, and PFDoDA were detected above LOD in 73.4% and 46.7% respectively. Parity, maternal age, maternal smoking, and fish intake during pregnancy were found to be significantly associated (p<0.05) with serum PFAS levels in the pregnant women. Finally, serum concentration of six PFAS (PFNA, PFDA, PFHxS, PFHpA, PFOA and PFOS) were significantly decreasing (range 14-31%) during the period of 30 months from 2007-2010. Conclusions Our analysis shows that six out of eight PFAS could be identified in serum of more than 99% of SELMA subjects with a significant slightly decreasing trend for five of these compounds. Furthermore, parity, higher fish intake and mothers age are determinants for serum levels of PFAS in pregnant women.

Place, publisher, year, edition, pages
Public library science , 2018. Vol. 13, no 12, article id e0209255
Keywords [en]
Perfluorinated alkyl acids; polyfluoroalkyl chemicals; prenatal exposure; dietary-intake; blood-serum; sweden; health; food; seafood; cohort
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
URN: urn:nbn:se:kau:diva-71052DOI: 10.1371/journal.pone.0209255ISI: 000454627200036PubMedID: 30596681OAI: oai:DiVA.org:kau-71052DiVA, id: diva2:1288754
Available from: 2019-02-14 Created: 2019-02-14 Last updated: 2020-01-09Bibliographically approved

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Shu, HuanBornehag, Carl-Gustaf

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