Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans
Karolinska Institutet.
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för hälsovetenskaper (from 2013).ORCID-id: 0000-0002-9739-7184
Uppsala University.
Karolinska Institutet.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 11315Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, Iow APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and Iow APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2018. Vol. 8, artikkel-id 11315
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
URN: urn:nbn:se:kau:diva-69376DOI: 10.1038/s41598-018-29732-9ISI: 000439965200008PubMedID: 30054528OAI: oai:DiVA.org:kau-69376DiVA, id: diva2:1250178
Tilgjengelig fra: 2018-09-21 Laget: 2018-09-21 Sist oppdatert: 2019-04-26bibliografisk kontrollert

Open Access i DiVA

Fulltext(1708 kB)34 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1708 kBChecksum SHA-512
86b95b56485c4f28e180631501d9da61b350cc40a59ef521bac952809ae664382d093370ca471969192fe16c15d670fe81b30a717dc0fc8c0541af0eec113240
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Lin, Ping-IBornehag, Carl-Gustaf

Søk i DiVA

Av forfatter/redaktør
Lin, Ping-ILindh, ChristianBornehag, Carl-Gustaf
Av organisasjonen
I samme tidsskrift
Scientific Reports

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 34 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 134 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf