Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Widespread episodic thiamine deficiency in Northern Hemisphere wildlife
Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, SE-10691 Stockholm, Sweden.
Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, SE-10691 Stockholm, Sweden.
Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, SE-10691 Stockholm, Sweden.
Stockholm Univ, Dept Environm Sci & Analyt Chem ACES, SE-10691 Stockholm, Sweden.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, artikel-id 38821Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Many wildlife populations are declining at rates higher than can be explained by known threats to biodiversity. Recently, thiamine (vitamin B-1) deficiency has emerged as a possible contributing cause. Here, thiamine status was systematically investigated in three animal classes: bivalves, ray-finned fishes, and birds. Thiamine diphosphate is required as a cofactor in at least five life-sustaining enzymes that are required for basic cellular metabolism. Analysis of different phosphorylated forms of thiamine, as well as of activities and amount of holoenzyme and apoenzyme forms of thiaminedependent enzymes, revealed episodically occurring thiamine deficiency in all three animal classes. These biochemical effects were also linked to secondary effects on growth, condition, liver size, blood chemistry and composition, histopathology, swimming behaviour and endurance, parasite infestation, and reproduction. It is unlikely that the thiamine deficiency is caused by impaired phosphorylation within the cells. Rather, the results point towards insufficient amounts of thiamine in the food. By investigating a large geographic area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemical alterations to secondary effects, we demonstrate that the problem of thiamine deficiency is considerably more widespread and severe than previously reported.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 2016. Vol. 6, artikel-id 38821
Nationell ämneskategori
Biologiska vetenskaper
Forskningsämne
Biologi
Identifikatorer
URN: urn:nbn:se:kau:diva-62599DOI: 10.1038/srep38821ISI: 000389688300001PubMedID: 27958327OAI: oai:DiVA.org:kau-62599DiVA, id: diva2:1130384
Tillgänglig från: 2017-08-09 Skapad: 2017-08-09 Senast uppdaterad: 2020-01-10Bibliografiskt granskad

Open Access i DiVA

Balk2016(2121 kB)3 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2121 kBChecksumma SHA-512
306674357ae027e854212162656564f46a36726330611184285bc8ce793c45ab74a9a16da8df03031e7d349fcfbcaa5709fe9b281c49439755bb108af428723a
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed
Av organisationen
Institutionen för miljö- och livsvetenskaper (from 2013)
I samma tidskrift
Scientific Reports
Biologiska vetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 3 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 95 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf