Artificial intelligence (AI) expects to increasingly transform ways in which business is conducted. With change follows a need to question current ways of acting and interacting. Yet, the past becomes the frames through which the future is understood. By drawing on Predictive Brain Theory, which shares the same fundamental underpinnings as the Bayesian brain hypothesis, but uses insights from machine learning and neuroscience, the paper conceptualizes that prospective sense making as a skill to update in-flux network pictures are increasingly required for business managers, which the paper reflects on in the light of AI. The paper provides a novel approach to business managers’ mental capacity in understanding change and in their ability to adapt to structural shifts that require an update on gone-solid assumptions about the business environment, while linking this to AI both as a motor of change, and as challenging the human thought with machine learning.