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Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för hälsovetenskaper.ORCID-id: 0000-0003-0417-1686
Cty Council Varmland, Karlstad, Sweden..
Lund Univ, Div Occupat & Environm Med, Lund, Sweden..ORCID-id: 0000-0002-8767-0589
Lund Univ, Div Occupat & Environm Med, Lund, Sweden..ORCID-id: 0000-0001-7435-9890
Vise andre og tillknytning
2015 (engelsk)Inngår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 123, nr 1, s. 101-107Artikkel i tidsskrift (Fagfellevurdert) Published
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Text
Abstract [en]

BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The anogenital distance (AGD)-the distance from the anus to the genitals-has been used to assess reproductive toxicity. OBJECTIVE: The objective of this study was to examine the associations between prenatal phthalate exposure and AGD in Swedish infants. METHODS: AGD was measured in 196 boys at 21 months of age, and first-trimester urine was analyzed for 10 phthalate metabolites of DEP (diethyl phthalate), DBP (dibutyl phthalate), DEHP, BBzP (benzylbutyl phthalate), as well as DiNP and creatinine. Data on covariates were collected by questionnaires. RESULTS: The most significant associations were found between the shorter of two AGD measures (anoscrotal distance; AGDas) and DiNP metabolites and strongest for oh-MMeOP [mono(4-methyl-7-hydroxyloctyl) phthalate] and oxo-MMeOP [mono-(2-ethyl-5-oxohexyl) phthalate]. However, the AGDas reduction was small (4%) in relation to more than an interquartile range increase in DiNP exposure. CONCLUSIONS: These findings call into question the safety of substituting DiNP for DEHP in soft PVC, particularly because a shorter male AGD has been shown to relate to male genital birth defects in children and impaired reproductive function in adult males and the fact that human levels of DiNP are increasing globally.

sted, utgiver, år, opplag, sider
2015. Vol. 123, nr 1, s. 101-107
Emneord [en]
Endocrine disrupting chemicals; in-utero exposure; male-rat; diisononyl phthalate; perinatal exposure; sexual development; gene-expression; dose-response; male infants; house-dust
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
URN: urn:nbn:se:kau:diva-41664DOI: 10.1289/ehp.1408163ISI: 000347385000020PubMedID: 25353625OAI: oai:DiVA.org:kau-41664DiVA, id: diva2:918421
Tilgjengelig fra: 2016-04-11 Laget: 2016-04-11 Sist oppdatert: 2018-01-10bibliografisk kontrollert

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Bornehag, Carl-GustafJonsson, Bo A. G.Lindh, Christian H.Janson, Staffan

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