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Relative importance of column and adsorption parameters on the productivity in preparative liquid chromatography II: Investigation of separation systems with competitive Langmuir adsorption isotherms
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper.
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper.ORCID-id: 0000-0003-1819-1709
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper.ORCID-id: 0000-0002-7123-2066
2014 (engelsk)Inngår i: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1347, s. 72-79Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this study we investigated how the maximum productivity for commonly used, realistic separation system with a competitive Langmuir adsorption isotherm is affected by changes in column length, packing particle size, mobile phase viscosity, maximum allowed column pressure, column efficiency, sample concentration/solubility, selectivity, monolayer saturation capacity and retention factor of the first eluting compound. The study was performed by generating 1000 random separation systems whose optimal injection volume was determined, i.e., the injection volume that gives the largest achievable productivity. The relative changes in largest achievable productivity when one of the parameters above changes was then studied for each system and the productivity changes for all systems were presented as distributions. We found that it is almost always beneficial to use shorter columns with high pressure drops over the column and that the selectivity should be greater than 2. However, the sample concentration and column efficiency have very limited effect on the maximum productivity. The effect of packing particle size depends on the flow rate limiting factor. If the pumps maximum flow rate is the limiting factor use smaller packing, but if the pressure of the system is the limiting factor use larger packing up to about 40μm.

sted, utgiver, år, opplag, sider
2014. Vol. 1347, s. 72-79
Emneord [en]
Numerical optimization, Preparative chromatography, Process optimization, Productivity
HSV kategori
Identifikatorer
URN: urn:nbn:se:kau:diva-34386DOI: 10.1016/j.chroma.2014.04.059ISI: 000336872800009PubMedID: 24831425ISBN: 00219673 (tryckt)OAI: oai:DiVA.org:kau-34386DiVA, id: diva2:755864
Tilgjengelig fra: 2014-10-15 Laget: 2014-10-15 Sist oppdatert: 2019-07-12bibliografisk kontrollert

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Forssén, PatrikSamuelsson, JörgenFornstedt, Torgny

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