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Prenatal phthalates exposure and the association to infant’s croup in the Swedish SELMA study
Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för hälsovetenskaper (from 2013).ORCID-id: 0000-0002-3395-2409
Örebro universitet.
Lunds universitet.
Lunds universitet.
Vise andre og tillknytning
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
URN: urn:nbn:se:kau:diva-62629OAI: oai:DiVA.org:kau-62629DiVA, id: diva2:1130755
Tilgjengelig fra: 2017-08-11 Laget: 2017-08-11 Sist oppdatert: 2019-06-17bibliografisk kontrollert
Inngår i avhandling
1. Phthalates: On the issue of sources, human uptake, time trends and health effects
Åpne denne publikasjonen i ny fane eller vindu >>Phthalates: On the issue of sources, human uptake, time trends and health effects
2017 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals. EDCs are manmade compounds (there are also natural compounds with such properties) that can bind to cell receptors and mimic or block the functions of natural hormones potentially resulting in adverse human health effects.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates. According to the World Health Organization, EDCs are suspected to be associated with altered reproductive function in males and females, increased incidence of breast cancer, abnormal growth patterns and neurodevelopmental delays in children, as well as changes in immune function.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children.

As we have shown, ongoing regulations on phthalates is of importance for human uptake. Ultimately, individuals can make small changes in their consumer product choices that can lead to changes in uptake of chemicals with endocrine disrupting properties. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

Abstract [en]

Human health depends on a well-functioning endocrine system to regulate hormone release for normal bodily functions. Endocrine disrupting chemicals (EDCs) constitutes a group of chemicals, included in many commonly used products, (e.g., PVC flooring), with properties proven or suspected to interact with the natural hormone system in humans and animals.

One type of widely concerning EDC is phthalates. Since phthalates create weak chemical bonds when they are added into different products, they readily leach into the surrounding environment. Phthalate metabolites can therefore be frequently measured in human biological samples. Major public health concerns regarding EDCs over the past three decades have focused on phthalates resulting in implementation of regulations.

The thesis shows that PVC flooring in the home is a source for human uptake of phthalates, that replacement of phthalates in soft PVC products have an impact on human uptake of these chemicals, and that exposure for phthalates in early life increase the risk for airway disorders in children. This means that regulation and consumers’ product choices can lead to changes in uptake of EDCs of importance for human health. Philosophically, we all have a responsibility to protect future generations from dangerous chemicals.

sted, utgiver, år, opplag, sider
Karlstads universitet, 2017. s. 61
Serie
Karlstad University Studies, ISSN 1403-8099 ; 2017:30
Emneord
Phthalates, Asthma, Pregnant, Exposure, Endocrine disrupting chemicals, SELMA
HSV kategori
Forskningsprogram
Folkhälsovetenskap
Identifikatorer
urn:nbn:se:kau:diva-62637 (URN)978-91-7063-806-0 (ISBN)978-91-7063-902-9 (ISBN)
Disputas
2017-09-29, 1B306 (Fryxellsalen), Universitetsgatan 2, Karlstad, 13:00 (engelsk)
Opponent
Veileder
Merknad

Paper 2 and 3 manuscript in thesis, now published.

Tilgjengelig fra: 2017-09-08 Laget: 2017-08-13 Sist oppdatert: 2019-06-17bibliografisk kontrollert

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