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Hegazy, M.-E. F., El-Beih, A. A., Moustafa, A. Y., Hamdy, A. A., Alhammady, M. A., Selim, R. M., . . . Pare, P. W. (2011). Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. Natural Product Communications, 6(12), 1809-1812
Open this publication in new window or tab >>Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
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2011 (English)In: Natural Product Communications, ISSN 1934-578X, E-ISSN 1555-9475, Vol. 6, no 12, p. 1809-1812Article in journal (Refereed) Published
Abstract [en]

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.

Keywords
Sarcophyton glaucum, cembrane diterpenes, dihydroxydeepoxysarcophine, sarcophine
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:kau:diva-40599 (URN)000298445300005 ()22312712 (PubMedID)
Available from: 2016-02-22 Created: 2016-02-22 Last updated: 2017-11-30Bibliographically approved
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6960-027X

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